Objective: To identify Fructus Schisandra chinensis and Fructus Schisandra Sphenanthera in Xiaochuanning Tablets. Method: Schisantherin A

schisandrin

deoxyschizandrin

schizandrin B served as the reference substances. The assay was conducted on SunFireTM C18 column (4.6 mm×150 mm

5 μm) with acetonitrile-tetrahydrofuran-water as mobile phase. The flow rate was 1.0 mL·min-1 and the detection wavelength was set at 254 nm. Similarity evaluation system for chromatographic fingerprint of TCM (2004 A) was used in data analysis. Result: Fructus Schisandra Chinensis from habitats were of strong similarity with those from Xiaochuanning Tablets

but the similarities with Fructus Schisandra Sphenanthera from habitats or tablets were less than 0.20. Conclusion: HPLC can be used for identification of Fructus Schisandra Chinensis and Fructus Schisandra Sphenanthera in Xiaochuanning Tablets.