HU Wei, FANG Yun, PENG Miao-miao. Study of Tissue Distribution of Compound Granules in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 156-160.
DOI:
HU Wei, FANG Yun, PENG Miao-miao. Study of Tissue Distribution of Compound Granules in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 156-160. DOI: 10.11653/syfj2013100156.
Study of Tissue Distribution of Compound Granules in Rats
Objective: To establish an HPLC method for the study of tissue distribution of compound Salvia plebeian granules in rats and provide theoretical basis for its clinical application. Method: The biological samples were extracted with acetonitrile
the Agilent TC-C18 (4.6 mm×250 mm
5 μm) column was used as analytical column with a mobile phase consisted of methanol and water(55: 45) at a flow rate of 1.0 mL·min-1. Result: The content of homoplantaginin was highest in stomach
and the concentration was (7.496±0.636) μg·g-1 after administration 1 hour later
then decreased to (5.237±0.373) μg·g-1 and (1.763±0.157) μg·g-1 after 4 h
7 h. Followed by kidney and small intestine
the content in heart
spleen and lung was relatively low. Conclusion: The homoplantaginin was distributed in all organs of rats after administrated compound S. plebeian granules. The higher distribution of homoplantaginin in kidney can be explained by the forming theory of urinary tract infection.
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Related Institution
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