Objective: To study the effect of 3'-daidzein sulfonate sodium adjusting sex hormone and estrogen receptor-α(ER-α) in prostatic hyperplasia tissue. Method: Thirty-two benign prostatic hyperplasia mice were modeled by subcutaneous injecting testosterone propionate for 12 consecutive days

and randomly grouped in four

including: the normal control group

the model group of prostatic hyperplasia

treatment groups with 20

40 mg·kg-1·d-1 of 3'-daidzein sulfonate sodium. After sacrificed the animal

prostate glandular wet weights

and it's propotion of total body weight

morphological changes of prostate gland

sex hormone including serum testosterone(T)

estrodiol(E2) contents

ER-α expression were measured. Result: 3'-daidzein sulfonate sodium could significantly inhibit testosterone propionate induced mouse benign prostatic hyperplasia

reduce the serum testosterone、estrodiol contents and the ratio of T/E2

and inhibit the expression of ER-α. Conclusion: 3'-daidzein sulfonate sodium has significant antagonistic effect on experimentally induced mouse benign prostatic hyperplasia by testosterone propionate

the mechanism which may related to the regulative impact on the balance of sex hormone and the expression of ER-α.