RUAN Xiao-fen, JIANG Mei-xian, XU Yu-ya, et al. Influence of Kanli Granule to Myocardial Energy Metabolism and Hemodynamic in the Rats Overloaded by Pressure[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 198-202.
DOI:
RUAN Xiao-fen, JIANG Mei-xian, XU Yu-ya, et al. Influence of Kanli Granule to Myocardial Energy Metabolism and Hemodynamic in the Rats Overloaded by Pressure[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 198-202. DOI: 10.11653/syfj2013100198.
Influence of Kanli Granule to Myocardial Energy Metabolism and Hemodynamic in the Rats Overloaded by Pressure
Objective: To study the influence of Kanli granule on myocardial energy metabolism and cardiac function. Method: Heart failure model were developed in rats by transverse aortic constriction(TAC). After 1 week of the operation
rats were treated orally with trimetazidine(0.36 mg·kg-1)
perindopril(5.4 mg·kg-1)
Kanli granule high-medium-low dose(13.5
6.75
3.38 mg·kg-1). After 32 weeks
myocardial energy metabolism and hemodynamic were examined. Result: Compared with group sham
LVSP(P<0.01) and LVEDP(P<0.05) was increased in model group
+dp/dtmax(P<0.01) and -dp/dtmax(P<0.05) was large in group BD
ATP
ATP/ADP was reduced (P<0.001) in model group BD;Compared with model group
LVEDP(P<0.05) were all reduced in group of Kainli granule
+dp/dtmax(P<0.05)
ATP was increased(P<0.05) in group M of Kainli granule. Conclusion: Kanli granule can improve left ventricular diastolic function
energy metabolism and improve the efficacy of cardiac structure and function.
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