Objective: To investigate the protective effects of Xingnao Zaizao capsules on vascular dementia in rats. Method: The rats were divided into sham-operation group

model group

Co-dergocrine Mesylate group(5 mg·kg-1)and three Xingnao Zaizao capsules groups at high

median and low doses(0.4

0.2

0.1 g·kg-1·d-1).VD rat models were reproduced by bilateral carotid artery occlusion.The learning and memory was assayed by Y maze.The cerebral blood flow was measured with the help of Laser Doppler flowmeter. At the end of the experiment

the rats were sacrificed and samples of brain tissues were used to determine the monoamine neurotransmitters by HPLC-FLD. Result: The time of correct response in the model group was significantly less than sham-operation group whose (P<0.01 or P<0.05)

and administered with Co-dergocrine Mesylate and Xingnao Zaizao capsules increased the correct response(P<0.01).Also

the cerebral blood flow were increased (P<0.05)

NE

DA

5-HT in brain tissueswere increased remarkably compared with model group (P<0.01 or P<0.05). Conclusion: Xingnao Zaizao capsules ameliorate the ability of learning and memory in VD rats

increase thecerebral blood flow

monoamineneurotransmittersin brain tissues.