Objective: To study the effect of Kang'ai injection combined with chemoradiation scheme on treating middle-late esophageal cancer. Method: Sixty-seven cases with middle-late esophageal cancer were randomly divided into observation group and control group

34 cases respectively. Two groups were all given radiation therapy and chemotherapy

the observation group supplemented by Kang'ai injection

60 mL

with 5% glucose 250 mL dilution by intravenous drip daily for 6 weeks as the treatment. The fatigue status was observed

and the quality of life and side reactions were evaluated for the two groups. Result: After treatment

the fatigue in observation group was significantly lighter than that in the control group (P<0.05); the score of life quality(57.54±4.77) in the observation group was better than that (51.45±6.12) in the control group (P<0.05). The Ⅲ degree suppression of bone marrow was 7 cases in observation group (20.58%)

lower than 15 cases in the control group of (45.45%) (P<0.05). The average appearance time in observation group was (21.5±5.7) d

later than (15.7±6.9) d of control group (P<0.01). The effective rate was 55.88% in observation group

and 39.39% in control group

the difference was not obvious. Conclusion: Kang'ai injection combined with chemotherapy and radiation for patients with middle-late esophageal cancer can reduce fatigue degree

reduce bone marrow suppression

delayed the appearance of Ⅲ degree bone marrow suppression and improve the patient's quality of life.