Effect of Shuxuening Injection on VEGF, vWF and MMP-9 in Patients with Acute Cerebral Infarction

WANG Hong-lian; LIU Li-jie; ZHAO Shu-qing

doi:10.11653/syfj2013100343

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Effect of Shuxuening Injection on VEGF, vWF and MMP-9 in Patients with Acute Cerebral Infarction

更新时间：2024-01-04

- Effect of Shuxuening Injection on VEGF, vWF and MMP-9 in Patients with Acute Cerebral Infarction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 10, Pages: 343-345(2013)
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- DOI：10.11653/syfj2013100343
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- Published：2013
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WANG Hong-lian, LIU Li-jie, ZHAO Shu-qing. Effect of Shuxuening Injection on VEGF, vWF and MMP-9 in Patients with Acute Cerebral Infarction[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 343-345.
DOI：

WANG Hong-lian, LIU Li-jie, ZHAO Shu-qing. Effect of Shuxuening Injection on VEGF, vWF and MMP-9 in Patients with Acute Cerebral Infarction[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 343-345. DOI： 10.11653/syfj2013100343.

摘要

目的: 探讨舒血宁注射液对急性脑梗死患者(ACI)血清血管内皮生长因子(VEGF)、血浆血管性血友病因子(vWF)和基质金属蛋白酶-9(MMP-9)的影响。方法: 80例ACI患者随机分为观察组和对照组各40例。两组均采用常规基础治疗

对照组采用依达拉奉30 mg

iv gtt

bid;观察组采用舒血宁注射液25 mg

iv gtt

疗程均为14 d。于治疗1

14 d

采用酶联免疫吸附试验测定血清VEGF

vWF

MMP-9水平;并按卒中量表(NIHSS)对神经功能进行评价。结果: 治疗后两组NHISS评分均呈下降趋势

14 d观察组NHISS评分低于对照组(P<0.05);治疗后观察组神经功能评价优于对照组(P<0.05);14 d观察组血清VEGF高于对照组(P<0.05)

观察组vWF和MMP-9水平低于对照组(P<0.05

P<0.01)。结论: 舒血宁注射液能改善ACI患者神经缺损功能

其作用机制可能与其调节VEGF

vWF

MMP-9水平有关。

Abstract

Objective: To observe the effects of Shuxuening injection on serum vascular endothelial growth factor (VEGF)

plasma von Willebrand factor (vWF) and matrix metalloproteinase-9 (MMP-9) in patients with acute cerebral infarction (ACI). Method: Eighty subjects with ACI were randomly divided into observation group (n=40) and control group (n=40). Both groups were received conventional treatment. The control group was given edaravone 30 mg ivgtt

bid; the observation group was given Shuxuening injection 25 mL ivgtt. qd

all for 14 days. The level of VEGF

vWF and MMP-9 were observed by enzyme-linked immunosorbent assay (ELISA) and neurologic function was evaluated. Result: The post-treatment NHISS scores of both groups showed a declining curve

the NHISS score of the observation group at 14 day was lower than that in the control group (P<0.05). The post-treatment neurological function evaluation of the observation group was superior to the control group (P<0.05). The level of serum VEGF of the observation group at 14 day was higher than the control group (P<0.05)

the level of vWF and MMP-9 in the observation group was lower than those in the control group (P<0.05

P<0.01). Conclusion: Shuxuening injection can improve neurologic impairment of patients with ACI

the mechanism may be related to the levels of VEGF

vWF and MMP-9.

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