Objective: To investigate applicability of ultrafiltration membrane with different materials in Qihong Maitong injection. Method: With transmissivity of active ingredients and bacterial endotoxin as indexes

4 kinds of different materials(polysulfone

polyether sulfone

polypropylene and blending) hollow fiber ultrafiltration membrane with the same entrapped relative molecular mass of 100 kDa were selected to ultrafiltrate.The removal of bacterial endotoxin and transmittance of active ingredients before and after ultrafiltration was detected by kenitie-turbidimetry method

which were adopted to determine the best appropriate ultrafiltration membrane material. Result: Polypropylene-100 kDa ultrafiltration membrane not only could effectively remove bacterial endotoxin

but also had a higher transmittance of active ingredients

it was suitable for purification of Qihong Maitong injection. Conclusion: Ultrafiltration could effectively remove bacterial endotoxin

while removal effect of bacterial endotoxin with different materials of ultrafiltration membranec was different.