Preparation and  Release Properties Investigation of Acetaminophen-Sodium Alginate-Carbon Nanotube Gels Microsphere

WAN Hong-shan; YUAN Qin; ZHAO Wei-yang

doi:10.11653/syfj2013110004

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Preparation and Release Properties Investigation of Acetaminophen-Sodium Alginate-Carbon Nanotube Gels Microsphere

更新时间：2024-01-04

- Preparation and Release Properties Investigation of Acetaminophen-Sodium Alginate-Carbon Nanotube Gels Microsphere
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 11, Pages: 4-7(2013)
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- DOI：10.11653/syfj2013110004
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- Published：2013
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WAN Hong-shan, YUAN Qin, ZHAO Wei-yang. Preparation and Release Properties Investigation of Acetaminophen-Sodium Alginate-Carbon Nanotube Gels Microsphere[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 4-7.
DOI：

WAN Hong-shan, YUAN Qin, ZHAO Wei-yang. Preparation and Release Properties Investigation of Acetaminophen-Sodium Alginate-Carbon Nanotube Gels Microsphere[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 4-7. DOI： 10.11653/syfj2013110004.

摘要

目的: 制备对乙酰氨基酚-海藻酸钠-碳纳米管(MWCNT)凝胶微球

并考察其体外释药性能。方法: 以对乙酰氨基酚(PCM)为模型药物

1-乙基-3(3-二甲基氨基丙基)碳化二亚胺(EDC)为相偶联剂

通过海藻酸钠(SAL)对碳纳米管(CNTs)进行修饰和改性

制备碳纳米管-海藻酸钠凝胶微球。借助FTIR分析、扫描电子显微镜表征修饰后MWCNTs的表面形貌

探讨PCM-SAL-MWCNT凝胶微球在人工肠液(SIF)中释放机制。结果: 修饰后的MWCNT凝胶微球载药量及在介质中释放量随凝胶微球中MWCNT含量的增加而减少

在模拟肠液中释放时间长且药物释放完全。结论: MWCNT可作为药物缓释载体材料。

Abstract

Objective: To prepare acetaminophen-sodium alginate-carbon nanotubes gels microsphere

and investigate its in vitro release properties. Method: With acetaminophen as a model drug

1-ethyl-3(3-dimethylamino-propyl) carbodiimide as a coupling agent

and surface properties were improved by sodium alginate in order to prepare acetaminophen-sodium alginate-carbon nanotubes gels microsphere.Surface morphology of modified acetaminophen-sodium alginate-carbon nanotubes gels microsphere was analysed by FTIR and characterized by scanning electron microscope

release mechanism of acetaminophen-sodium alginate-carbon nanotubes gels microsphere artificial intestinal fluid was investigated. Result: After modified

drug loadings and release amount in medium of acetaminophen-sodium alginate-carbon nanotubes gels microsphere decreased with increasing the content of carbon nanotubes in this gels microsphere

and this gels microsphere showed a long time of release and drug release completely in simulated intestinal fluid. Conclusion: Multi-walled carbon nanotubes could be used as a drug delivery carrier for sustained-release preparations.

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