JIA Yong-yan, YUAN Yu-xia, ZHOU Ning, et al. Optimization of Preparation Technology of Coptis Total Alkaloids Gelatin Microsphere[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 11-13.
DOI:
JIA Yong-yan, YUAN Yu-xia, ZHOU Ning, et al. Optimization of Preparation Technology of Coptis Total Alkaloids Gelatin Microsphere[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 11-13. DOI: 10.11653/syfj2013110011.
Optimization of Preparation Technology of Coptis Total Alkaloids Gelatin Microsphere
Objective: To optimize preparation technology of Coptis total alkaloids gelatin microsphere. Method: Coptis total alkaloids gelatin microsphere was prepared by emulsified cross linking method
with composite score of encapsulation efficiency and drug loading as index
effects of the concentration of gelatin
the dosage of crosslinking agent
feeding dosage and ratio of oil phase-water phase on preparation technology was investigated by orthogonal design. Result: Optimal preparation technology was obtained with the concentrations of gelatin 12%
the dosage of Coptis total alkaloids 1.7%
ratio of water phase to oil phase 1:12
the dosage of crosslinking agent 15%.These drug loaded microsphere were spherical with smooth surface
encapsulation efficiency was 63.7%
drug loading was 6.50%. Conclusion: This optimized preparation technology was reliable and stable