Objective: To prepare dehydroandrographolide self-emulsifying formulation and evaluate its quality. Method: Types of prescription accessories were screened by solubility test;With emulsifying effect

emulsification equilibrium time

particle size and distribution of this emulsions

accessories were determined by orthogonal test

and optimum prescription was determined by combining with ternary phase diagrams.After diluted

appearance

particle size

Zeta potential and stability of this formulation were investigated. Result: Optimum prescription of dehydroandrographolide self-emulsifying formulation was as following:mtween-80: mMCT:mglycerin=50:20:30

particle size of 23.7 nm

Zeta potential of -14.47 mV.Self-emulsifying speed was rapid

and it had good stability at room temperature for 3 months. Conclusion: This optimized preparation technology was simple with fast emulsifying time and small particle size

prepared self-emulsifying formulation was clear and transparent with stable quality.