Optimization of Formulation Technology for Andrographolide Oral Suspensions by Orthogonal Test

WANG Fang; LI Yan-li; ZHAI Wen-ting; XU Hui

doi:10.11653/syfj2013110042

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Optimization of Formulation Technology for Andrographolide Oral Suspensions by Orthogonal Test

更新时间：2024-01-04

- Optimization of Formulation Technology for Andrographolide Oral Suspensions by Orthogonal Test
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 11, Pages: 42-44(2013)
- 作者机构：
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- DOI：10.11653/syfj2013110042
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- Published：2013
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WANG Fang, LI Yan-li, ZHAI Wen-ting, et al. Optimization of Formulation Technology for Andrographolide Oral Suspensions by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 42-44.
DOI：

WANG Fang, LI Yan-li, ZHAI Wen-ting, et al. Optimization of Formulation Technology for Andrographolide Oral Suspensions by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 42-44. DOI： 10.11653/syfj2013110042.

摘要

目的: 优选穿心莲内酯混悬剂的处方工艺。方法: 采用分散法制备穿心莲内酯混悬剂

以沉降体积比、再分散性和溶出度的综合评分为指标

采用正交试验优选处方。结果: 最佳处方工艺为每1 mL混悬剂含穿心莲内酯100 mg

羧甲基纤维素钠5 mg(0.5%)

甘油5 mg(0.5%)。制得穿心莲内酯混悬剂的沉降体积比0.99

再分散性良好

1 h溶出度99.59%。结论: 优选的处方工艺稳定可行

制剂的物理稳定性良好

符合混悬剂的质量要求。

Abstract

Objective: To optimize formulation technology of andrographolide suspensions. Method: Andrographolide suspensions were prepared by dispersion method.Prescription was optimized by orthogonal test with composite score of sedimentation ratio

re-dispersibility and dissolution as index. Result: Optimum formulation technology was composed of andrographolide 100 mg

glycerol 5 mg (0.5%) and carboxymethyl-cellulose sodium 5 mg (0.5%) per 1 mL suspensions.These prepared andrographolide suspensions showed satisfactory properties including 99% sedimentation ratio and 100% re-dispersibility with dissolution of 99.59% in 1 hour. Conclusion: This optimized formulation technology was stable and feasible

and the obtained andrographolide suspensions had good physical stability which met quality requirements of suspensions.

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Related Institution

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