TONG Yan, LI Xiao-fei, WANG Xian-ling, et al. Molecular Docking Study on Constituents of Radix Bupleuri and Radix Scutellare and Cycloxygenase[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 148-151.
DOI:
TONG Yan, LI Xiao-fei, WANG Xian-ling, et al. Molecular Docking Study on Constituents of Radix Bupleuri and Radix Scutellare and Cycloxygenase[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 148-151. DOI: 10.11653/syfj2013110148.
Molecular Docking Study on Constituents of Radix Bupleuri and Radix Scutellare and Cycloxygenase
Objective: Radix Bupleuri and Radix Scutellare in compatibility on liver injury induced by alcohol and hepatocellular carcinoma have been verified by experiments. Method: In this study
four active chemical components of Radix Bupleuri and Radix Scutellare were docked with cycloxygenase(COX-2)
respectively. The binding mode and docking energy of those components with COX-2 were analyzed. Result and Conclusion: It has been found that saikosaponin A and saikosaponin D in Radix Bupleuri have no binding capability with COX-2 and baicalin and baicalein in Radix Scutellare have strong binding capability with COX-2.
Investigation on Anti-liver Cancer Potential and Compatibility Characteristics of Fufang Biejia Ruangan Pian from Network Perspective
Screening of Antitumor Active Components and Key Targets of Aconiti Lateralis Radix Praeparata-Pinelliae Rhizoma Based on PI3K/Akt Pathway
Effect of Compatibility of Astragalus and Different Dose Radix Bupleuri on the Model of Spleen-qi Deficiency with Fever in Rats
Interaction Between Cycloxygenase-2 and Main Active Chemical Components of Bupleuri Radix and Scutellariae Radix
Effect of Radix Bupleuri Combined with Radix Paeoniae Alba in Treatment of PMDD Liver Qi Stagnation Syndrome
Related Author
Wen-jia CHEN
Xia MAO
Xiao-dong GUO
Ling-xiang YU
Na LIN
Yan-qiong ZHANG
Xin YANG
Ya-hui LI
Related Institution
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
The Fifth Medical Center of PLA General Hospital
Guiyang University of Chinese Medicine
Key Laboratory of Chemistry and Engineering of Forest Products, National Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products/Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University
Guangxi Key Laboratory of Chinese Medicine Quality Standard, Guangxi Institute of Chinese Medicine and Pharmaceutical Science