Studies on Pharmacokinetics of Multi-constituents of Atractylis Oil based on Chromatographic Fingerprint

TAO Ye; ZHANG Bei-bei; FU Mei-hong; XU Hai-yu; FANG Jing; WANG Wei-hao; LI De-feng; Zhang Yi; YANG Hong-jun

doi:10.11653/syfj2013110156

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Studies on Pharmacokinetics of Multi-constituents of Atractylis Oil based on Chromatographic Fingerprint

更新时间：2024-01-04

- Studies on Pharmacokinetics of Multi-constituents of Atractylis Oil based on Chromatographic Fingerprint
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 11, Pages: 156-159(2013)
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- DOI：10.11653/syfj2013110156
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- Published：2013
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TAO Ye, ZHANG Bei-bei, FU Mei-hong, et al. Studies on Pharmacokinetics of Multi-constituents of Atractylis Oil based on Chromatographic Fingerprint[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 156-159.
DOI：

TAO Ye, ZHANG Bei-bei, FU Mei-hong, et al. Studies on Pharmacokinetics of Multi-constituents of Atractylis Oil based on Chromatographic Fingerprint[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 156-159. DOI： 10.11653/syfj2013110156.

摘要

目的: 建立了茅苍术挥发油中7个成分的体内分析方法。方法: 采用内标法测定了给药后不同时间点7个化合物的血药浓度

并通过DAS 3.0软件计算出药代动力学参数

以自定义各成分的权重系数进行茅苍术挥发油整合药代动力学研究

分别获得化合物 1~7 及其整合的血浆浓度-时间曲线

化合物 2~7 和整合的药动学参数。结果: 整合药动学参数T1/2

Tmax

Cmax

AUC(0-∞)和MRT(0-∞)分别为8.01

4.00 h

3.84 mg·L-1

42.31 mg·L-1·h-1

11.65 h。结论: 研究思路符合中医药作用特点

对多组分苍术挥发油的药代动力学做了一些初步的探索。

Abstract

Objective: To investigate pharmacokinetics process of the major components of Atractylodes lancea oil in rats. Method: A preliminary HPLC method based on internal standard method was employed to analysis 7 constituents simultaneously in plasma and to study their pharmacokinetics after oral administration of volatile oil from A. lancea in rats. Pharmacokinetic parameters of compound 2~7 were acquired by DAS 3.0 software and the integrative concentration-time curve was obtained based on the corresponding weighting coefficients. Result: Integrative pharmacokinetic parameters was as follows: T1/2 was 8.01 h

Tmax was 4.00 h

Cmax was 3.84 mg·L-1

AUC(0-∞) was 42.31 mg·L-1·h-1 and MRT(0-∞) was 11.65 h

respectively. Conclusion: This study was thought as an appropriate method for traditional Chinese medicine and we carried out some exploratory survey for pharmacokinetics of volatile oil from A. lancea.

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Related Institution

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