Objective: To investigate the effects of tilianin on the level of serum lipids and inflammatory factors in rats. Method: Sixty male Wistar rats were randomly divided into 6 groups

normal control group

model control group

simvastatin group (2.5 mg·kg-1·d-1)

tilianin high does group (5.0 mg·kg-1·d-1)

tilianin medium does group (2.5 mg·kg-1·d-1)

tilianin low does group (1.5 mg·kg-1·d-1). Rats in normal control group were given ordinary diet

and rats in other groups were given high fat diet and perfused with vitamin D3 twice to establish the atherosclerosis model. After 12 weeks

the levels of total cholesterol (TC)

triglyceride (TG)

low density lipoprotein cholesterol(LDL-C)

high density lipoprotein cholesterol(HDL-C)

interleukin-1 (IL-1)

IL-6

tumor necrosis factor alpha (TNF-α) and high sensitivity C reactive protein (hs-CRP) in serum were determined. Result: Compared with normal control group after 12 weeks

the level of TC(29.6±3.52)mmol·L-1

TG(2.63±0.41) mmol·L-1

LDL-C(5.51±0.76) mmol·L-1

IL-1(18.3±1.86) ng·L-1

IL-6(49.7±6.77)ng·L-1

TNF-α(68.5±8.26) ng·L-1

hs-CRP(11.1±1.14)μg·L-1 in model control group were increased significantly

and HDL-C (2.87±0.52)mmol·L-1 level was decreased significantly

(P<0.01). Compared with model group

tilianin groups could decrease the content of TC

TG

LDL-C

IL-1

IL-6

TNF-α

hs-CRP and increase the content of HDL-C (P<0.01

P<0.05) in serum. Conclusion: Tilianin may inhibit atherosclerotic formation in rats by its regulatory lipid and anti-inflammatory effects.