Objective: To study the antitussive and expectorant activity of different extracts from the crude and honey-stir-baked Tussilago farfara flower. Method: Antitussive experiment:Mice were randomly divided into the normal control group

the negative control group(the solvent)

the positive control group (pentoxyverine citrate

0.01 g·kg-1)

the high

low-dose group of aqueous extract (6.20

3.10 g·kg-1)

the high

low-dose group of alcohol extract (6.0

3.0 g·kg-1)

the high

low-dose group of ether and ethyl acetate extract (0.5

0.25 g·kg-1) from the crude and honey-stir-baked T. farbara flower. The intragastric administration volume was 25 mL·kg-1 for 5 days. The latent period of cough and frequency of cough in 2 min were determined after 25% ammonia quantitative spray. Expectorant experiment: SD rats were randomly divided into the normal control group

the negative control group

the positive control group (NH4Cl

0.16 g·kg-1)

the high

low-dose group of aqueous extract (2.70

1.35 g·kg-1)

the high

low-dose group of alcohol extract (3.0

1.5 g·kg-1)

the high

low-dose group of ether and ethyl acetate extract (0.25

0.125 g·kg-1) from the crude and honey-stir-baked T. farbara flower. The intragastric administration volume was 25 mL·kg-1 for 3 days. The secretory volume of sputum was determined by glass capillary method after 2 h of the last administration. Result: Compared with model control group

Ethanol extracts of the crude and honey-stir-baked T. farfara flower had strong antiasthmatic activity

could prolong the latent period of cough (P<0.05) and reduce the frequency of cough (P<0.05) significantly. At the same time

aqueous extracts of the crude and honey-stir-baked T. farfara flower had some antitussive effect. Expectorant experiment: compared with model control group

the volume of sputum was increased significantly (P<0.05) in high

low-dose group of aqueous extract from honey-stir-baked T. farfara flower

low-dose group of ethyl acetate extract from crude T. farfara flower and high dose group of ethyl acetate extract from honey-stir-baked T. farfara flower. Moreover

the body weight of mice significantly reduced in the group of different solvent extracts from crude T. farfara flower (P<0.05). Conclusion: T. farfara flower has antitussive and expectorant activity. Its antitussive ingredients possess high-polarity and are soluble in water and ethanol freely;But its expectorant ingredients possess low-polarity and are fat-soluble. At the same time

different solvent extracts of crude T. farfara flower may have some toxicity.