Anti-fatigue Effect and Mechanism of Flavonoids from Mori Folium

MA Xiang-qian; HU Ying

doi:10.11653/syfj2013110216

您当前的位置：

首页 >

文章列表页 >

Anti-fatigue Effect and Mechanism of Flavonoids from Mori Folium

更新时间：2024-01-04

- Anti-fatigue Effect and Mechanism of Flavonoids from Mori Folium
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 11, Pages: 216-219(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013110216
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
MA Xiang-qian, HU Ying. Anti-fatigue Effect and Mechanism of Flavonoids from Mori Folium[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 216-219.
DOI：

MA Xiang-qian, HU Ying. Anti-fatigue Effect and Mechanism of Flavonoids from Mori Folium[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 216-219. DOI： 10.11653/syfj2013110216.

摘要

目的: 研究桑叶总黄酮抗疲劳作用并探讨其作用机制。方法: 将小鼠分为桑叶总黄酮高、低剂量组(桑叶总黄酮1

0.4 g·kg-1)、肌酸给药组(肌酸3 g·kg-1)、阴性对照组和正常对照组(0.9%生理盐水)

给药14 d后小鼠进行负重力竭游泳实验(除正常对照组外)

采血分离血清

测定与疲劳有关的生化指标

应用体外自由基清除实验及小鼠肝组织脂质自氧化法测定桑叶总黄酮抗氧化及清除自由基能力。结果: 与阴性对照组比较

小鼠给药桑叶总黄酮后负重游泳时间明显延长(P<0.05或P<0.01)

血清肌酐和尿素氮浓度降低

丙二醛的生成受到抑制(P<0.05或P<0.01)。结论: 桑叶总黄酮具有抗疲劳、清除自由基、抑制小鼠肝脏组织脂质自氧化的活性。其抗疲劳能力与其较强的自由基的清除作用相关。

Abstract

Objective: To study the anti-fatigue effect of flavonoids from Mori Folium and discuss its mechanism. Method: Male Kunming mice were randomly divided into groups of flavonoids group (0.4

1g·kg-1 mulberry leaves flavonoids

respectively)

creatine group (creatine 3 g·kg-1)

control and normal group (stomach irritation with saline only). The exhaustive swimming experiment was performed 14 days later. The time of exhaustive swimming of mice was recorded and chemistry parameters correlated with fatigue was determined. The effects of flavones of Mori Folium on scavenging free radicals and anti-oxidation were investigated in vitro. Result: The time of exhaustive swimming of flavonoids groups and creatine group was longer than that of control group (P<0.05). The content of the creatinine and urea nitrogen level of serum decreased significantly the MDA production in liver tissues of mice in flavonoids group is lower than that of control group (P<0.05). Conclusion: Flavonoids from Mori Folium can improve the anti-fatigue capacity obviously and has a significant effect on scavenging free-radicals. The anti-fatigue effect of total flavonoids from Mori Folium may have correction with its radicals scavenging effects.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Antioxidant Activity of Constituents from

Effect of Polysaccharides from Root， Stem， Leaf and Fruit of Schisandra chinensis on Exercise Endurance in D-galactose-induced Aging Mice

Investigation on in Vitro Antioxidant Activity and Chemical Composition of Different Polar Parts of Extract of Rosa cymosa Roots

Changes in Effective Compounds and Anti-fatigue Activity Before and After Compatibility of Ginseng Radix et Rhizoma Rubra and Rhodiolae Crenulate Radix et Rhizoma

Promotive Effect of Jufeng Ⅰ,Ⅱ Oral Liquids on the Sport Activity in Mice

Related Author

DANG Cui-zhi

HANG Xiao-yan

YANG Qing-xiong

AI Jun-li

TIAN Meng

Jia-hui FANG

Jia-wei LIU

Yu-xin JIANG

Related Institution

College of Pharmacy， Beihua University

Affiliated Hospital of Beihua University

National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines， Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

School of Pharmacy， Hunan University of Chinese Medicine

Zhuzhou Qianjin Pharmaceutical Co. Ltd.

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰