Effect of the Treatment of Jianpi Huayu Jiedu for Patients with Chronic Atrophic Gastritis and its Influence on Cyclin E Protein Expression

GUO Ya-lei; RAO Jing; PAN Hua-feng; FANG Jia

doi:10.11653/syfj2013110292

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Effect of the Treatment of Jianpi Huayu Jiedu for Patients with Chronic Atrophic Gastritis and its Influence on Cyclin E Protein Expression

更新时间：2024-01-04

- Effect of the Treatment of Jianpi Huayu Jiedu for Patients with Chronic Atrophic Gastritis and its Influence on Cyclin E Protein Expression
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 11, Pages: 292-295(2013)
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- DOI：10.11653/syfj2013110292
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- Published：2013
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GUO Ya-lei, RAO Jing, PAN Hua-feng, et al. Effect of the Treatment of Jianpi Huayu Jiedu for Patients with Chronic Atrophic Gastritis and its Influence on Cyclin E Protein Expression[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 292-295.
DOI：

GUO Ya-lei, RAO Jing, PAN Hua-feng, et al. Effect of the Treatment of Jianpi Huayu Jiedu for Patients with Chronic Atrophic Gastritis and its Influence on Cyclin E Protein Expression[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 292-295. DOI： 10.11653/syfj2013110292.

摘要

目的: 观察健脾化瘀解毒法对慢性萎缩性胃炎(CAG)癌前病变(PLGC)病人的疗效以及对细胞周期蛋白E (Cyclin E protein)表达的影响。方法: 60例患者随机分为治疗组和对照组各30例。另设10例健康对照组。对照组采用胃复春片

4片/次

3次/d。治疗组采用健脾化瘀解毒方治疗

常规水煎服分3次服用

1剂/d。疗程均为24周。观察两组的临床疗效、胃镜、病理及幽门螺杆菌(HP)的改变;测定Cyclin E蛋白的表达量。结果: 治疗组总有效率93.33%

对照组总有效率86.67%

差异不明显;治疗组胃镜总有效率(80.00)优于对照组(60.00%)(P<0.05);治疗组病理疗效总有效率(76.67%)优于对照组(60.00%)(P<0.05);治疗组HP根除率(68.18%)明显优于对照组(21.05%)(P<0.05);两组治疗后Cyclin E蛋白的表达均降低

治疗组降低更显著(P<0.01)。结论: 健脾化瘀解毒法能提高CAG胃镜及病理疗效

HP根除率高;健脾化瘀解毒法能调节Cyclin E蛋白的表达

从而阻止胃癌前病变发展。

Abstract

Objective: To observe the clinical effect of the treatment of Jianpi Huayu Jiedu for the patients with chronic atrophic gastritis and its influence on the Cyclin E protein expression. Method: Sixty cases were divided into control group and treatment group (n=30 each) randomly. Another 10 persons were selected as the healthy controls. The patients in the control group were given Weifuchun tablets of 4 tid. The cases in the treatment group were received Jianpi Huayu Jiedu decoction (one decoction divided taken 3 times daily). Clinical effect

endoscopic images

pathological changes and the effect on helicobacter pylori (HP) were observed in each group. The expression of Cyclin E protein in every group was investigated using immunohistochemistry. Result: The total effect in treatment group was 93.33%

that of the control group was 86.67%

having no significant difference. The endoscopic images (80.00%)

pathological changes (76.67%) and the HP eradication rate (68.18%) in the treatment group were better than those (60.00%

60.00% and 21.05%) in the control group

having significant difference (P<0.05). The expression of Cyclin E protein was decreased after treatment in the both treatment group and control group

and the treatment group was also better than control group

with significant difference (P<0.01). Conclusion: The treatment of Jianpi Huayu Jiedu can influence the expression of the Cyclin E protein in the patients with precancerous lesion of gastric carcinoma

so it may prevent the development of precancerous lesion of gastric carcinoma.

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