Objective: To observe the conservative treatment of acute uncomplicated appendicitis by traditional Chinese medicine with different routes. Method: Ninety-two cases of acute uncomplicated appendicitis patients were randomly divided into observation group and the control group (n=46 each). Both groups were given fasting

nutritional support; symptomatic treatment

anti-infection by antibiotics. On this basis

the observation group was received decoctions of Chinese herbs

Chinese medicinal enema and external application of Chinese medicine at appendix area. The treatment lasted for 7 d. After the treatment 1-3 d

the fever

the abdominal pain

the tenderness

the nausea

the vomiting and the other symptoms

the physical signs and the abdominal pain

the tenderness to restore the normal time were observed. Result: The total effective rate of 93.47% in the observation group was better than 78.26% in the control group (P<0.05). After the treatment of 2 and 3 days

the fever

the abdominal pain

the tenderness

the nausea

the vomiting and the other symptoms and signs in the observation group were improved significantly better than those in the control group (P<0.05). The time required for body temperature to return normal

abdominal pain and tenderness to relieve in the observation group was significantly less than those in the control group (P<0.01). Conclusion: Chinese conservative treatment with different routes for acute uncomplicated appendicitis could quickly control the clinical symptoms of fever

pain

tenderness

nausea and vomiting

could improve the clinical efficacy.