SHI Jun-han, ZHANG Xing-fen, QIU Ji-xi, et al. Investigation of Bitter Masking Mechanism of -cyclodextrin to Several Traditional Chinese Medicines[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 1-4.
DOI:
SHI Jun-han, ZHANG Xing-fen, QIU Ji-xi, et al. Investigation of Bitter Masking Mechanism of -cyclodextrin to Several Traditional Chinese Medicines[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 1-4. DOI: 10.11653/syfj2013120001.
Investigation of Bitter Masking Mechanism of -cyclodextrin to Several Traditional Chinese Medicines
Objective: To study the mechanism of bitter taste masking by β-cyclodextrin(β-CD) for traditional Chinese medicine(TCM). Method: With decoction of Phellodendri Chinensis Cortex
Gentianae Radix et Rhizma
Andrographis Herba
et al. and water solution of berberine as model drugs
sulfobutyl ether-β-CD(SBE-β-CD) and β-CD as taste masking agent
the degree of bitter before and after masking was evaluated by mouth-tasting. Result: β-CD showed more significant effects of bitter taste masking than SBE-β-CD
except Gentianae Radix et Rhizma. Conclusion: This study proved that β-CD could used as taste-masking agent for decoction of several TCM.