Optimization of Formulation Technology for Gastric Floating Tablets of Total Glucosides from

SHI Zhi-qi; WANG Luo-lin; DU Jian-ping; FU Jian-wu

doi:10.11653/syfj2013120015

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Optimization of Formulation Technology for Gastric Floating Tablets of Total Glucosides from

更新时间：2024-01-04

- Optimization of Formulation Technology for Gastric Floating Tablets of Total Glucosides from
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 12, Pages: 15-18(2013)
- 作者机构：
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- DOI：10.11653/syfj2013120015
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- Published：2013
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SHI Zhi-qi, WANG Luo-lin, DU Jian-ping, et al. Optimization of Formulation Technology for Gastric Floating Tablets of Total Glucosides from [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 15-18.
DOI：

SHI Zhi-qi, WANG Luo-lin, DU Jian-ping, et al. Optimization of Formulation Technology for Gastric Floating Tablets of Total Glucosides from [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 15-18. DOI： 10.11653/syfj2013120015.

摘要

目的: 优选积雪草总苷胃漂浮片的处方工艺。方法: 采用干粉直接压片制备积雪草总苷胃漂浮片

以漂浮性能和体外释药性能为指标

通过单因素试验及混料设计试验优选胃漂浮片的处方参数

确定最优处方。结果: 最佳处方工艺为25%积雪草总苷

28.6% HPMC

15.6% NaHCO3

20.8% CMS-Na

10% PEG 20000。起漂时间(3.2±0.2) min

持漂时间>12 h

体外释放符合零级动力学模型。结论: 制备的胃漂浮片具有优良的漂浮能力和释药行为

可增加积雪草总苷在胃部的滞留时间

提高对胃溃疡的疗效。

Abstract

Objective: To optimize formula of gastric floating tablets of total glucosides from Centella asiatica. Method: Gastric floating tablets were prepared by direct compression with dry powder.With floating properties and in vitro release as indexes

single factor tests and mixture design test were adopted to optimize formulation parameters which impacted properties of gastric floating tablets of total glucosides from C. asiatica. Result: Optimum formulation included 25% total glucosides from C. asiatica

28.6% HPMC K15M

15.6% NaHCO3

20.8%CMS-Na and 10%PEG20000.The results showed that these products could float within (3.2±0.2) min and maintain for over 12 h

in vitro release of this tablets fitted zero-order kinetics model. Conclusion: These prepared gastric floating tablets showed a good sustained-release and continual floating property

it could increase residence time and improve efficacy for gastric ulcer.

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