Investigation of  Transdermal Property of Hydroxysafflor Yellow A in Guyu Prescription

WEN Ran; HAO Bo; GAO Ying; LU Yang; LI Hui-yun; ZHAO Xue-jiao

doi:10.11653/syfj2013120040

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Investigation of Transdermal Property of Hydroxysafflor Yellow A in Guyu Prescription

更新时间：2024-01-04

- Investigation of Transdermal Property of Hydroxysafflor Yellow A in Guyu Prescription
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 12, Pages: 40-42(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013120040
  CLC：
- Published：2013
- 稿件说明：
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WEN Ran, HAO Bo, GAO Ying, et al. Investigation of Transdermal Property of Hydroxysafflor Yellow A in Guyu Prescription[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 40-42.
DOI：

WEN Ran, HAO Bo, GAO Ying, et al. Investigation of Transdermal Property of Hydroxysafflor Yellow A in Guyu Prescription[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 40-42. DOI： 10.11653/syfj2013120040.

摘要

目的: 研究骨愈方中羟基红花黄色素A的体外透皮释药情况。方法: 采用垂直式Franz扩散池进行小鼠离体皮肤透皮吸收试验

以羟基红花黄色素A(HSYA)含量为指标

考察乙醇体积分数和药物浓度对HSYA透皮性能的影响。结果: 药液质量浓度和乙醇体积分数的增加均有利于HSYA透过皮肤;选择生药质量浓度1 g·mL-1

乙醇体积分数70%。结论: 70%乙醇可显著促进HSYA的皮肤透过作用

为骨愈搽剂的制备提供参考。

Abstract

Objective: To investigate in vitro transdermal behavior of hydroxysafflor yellow A(HSYA) in Guyu prescription. Method: Percutaneous absorption test was performed on excised mice skin in Franz diffusion cell

with the content of HSYA as index

effect of the concentration of ethanol and drug on transdermal property of HSYA was investigated. Result: The accumulation skin permeation ratio of HSYA with 20% ethanol

50% ethanol and 70% ethanol were 1.26%

1.69%

5.28%

respectively;And results of 0.5

2 g·mL-1 of drug solution were 1.06%

1.26%

1.50%

respectively.Increasing of the concentration of ethanol and drug solution were conducive HSYA through skin;the concentration of 1 g·mL-1 and 70% were selected. Conclusion: 70% ethanol could significantly promote transdermal property of HSYA

it could provide a reference for preparing Guyu liniments.

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Related Author

Yan-fen CHENG

Sheng-ju WANG

Yi-han WU

Xiao WANG

Ting WANG

Jin PEI

Jin-ming ZHANG

Chao-mei FU

Related Institution

College Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province, Key Laboratory Breeding Base of Co-founded by Sichuan Province and Ministry of Science and Technology

Gansu Provincial Institute of Food and Drug Control,Gansu Province Traditional Chinese Medicine Quality and Safety Evaluation of Engineering Technology Research Center

College of Chinese Medicine,Shanghai University of Traditional Chinese Medicine

Shanghai Zerun Biotechnology Co.Ltd

College of Pharmacy,Liaoning University of Traditional Chinese Medicine

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