Transdermal Absorption Test of Ursolic Acid in

NURULLA Pahirdin; Turghun Kadir; SHEN Teng; XIERAILI Tuerxun

doi:10.11653/syfj2013120049

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Transdermal Absorption Test of Ursolic Acid in

更新时间：2024-01-04

- Transdermal Absorption Test of Ursolic Acid in
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 12, Pages: 49-52(2013)
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- DOI：10.11653/syfj2013120049
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- Published：2013
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NURULLA Pahirdin, Turghun Kadir, SHEN Teng, et al. Transdermal Absorption Test of Ursolic Acid in [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 49-52.
DOI：

NURULLA Pahirdin, Turghun Kadir, SHEN Teng, et al. Transdermal Absorption Test of Ursolic Acid in [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 49-52. DOI： 10.11653/syfj2013120049.

摘要

目的: 考察白花蛇舌草中熊果酸的透皮吸收特性。方法: 采用HPLC测定熊果酸含量。选择SD大鼠背部皮肤

通过Franz垂直扩散池考察熊果酸的透皮性能

并考察氮酮(azone)、桉叶油、冰片、白花蛇舌草水提取物和醇提取物对熊果酸透皮吸收的影响。结果: 熊果酸很难透过皮肤

需加入透皮吸收促进剂才能有效地透过皮肤。不同质量分数促进剂对熊果酸促透作用顺序为5%醇提物>5%醇提物+2%冰片>5%水提物>2%azone+10%丙二醇(PG)>2%桉叶油>4%azone>3%桉叶油>2%azone>1%azone。结论: Azone和桉叶油是白花蛇舌草中熊果酸的良好促透剂

复方水提取物和醇提物具有协同促透的作用。

Abstract

Objective: To investigate transdermal absorption characteristics of ursolic acid in Hedyotis diffusa. Method: The content of ursolic acid was determined by HPLC.Utilized skin on the back of SD rats

Franz vertical diffusion cell was adopted to investigate transdermal performance of ursolic acid

and effect of azone

eucalyptus oil

synthetic borneol

water extract and alcohol extract of H. diffusa on transdermal performance of ursolic acid was investigated. Result: Ursolic acid was difficult to penetrate the skin

it must be added to certain transdermal absorption enhancer.Effect of enhancers on ursolic acid was in order of 5% ethanol extract>5% ethanol extract+2% borneol>5% water extract>2% azone+10% PG>2% eucalyptus oil>4% azone>3% eucalyptus oil>2% azone>1% azone. Conclusion: Azone and eucalyptus oil was good penetration enhancers for ursolic acid in H. diffusa

compound water extract and ethanol extract had a collaborative effect in promoting penetration.

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