Determination of Glycerin in Ibuprofen Oral Solution by HPLC-RID

LI Yan-gang; LUO Li-ping; YANG Wu-liang; GUO Li-rong; CHENG Fei; WANG Zhen

doi:10.11653/syfj2013120061

您当前的位置：

首页 >

文章列表页 >

Determination of Glycerin in Ibuprofen Oral Solution by HPLC-RID

更新时间：2024-01-04

- Determination of Glycerin in Ibuprofen Oral Solution by HPLC-RID
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 12, Pages: 61-63(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013120061
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
LI Yan-gang, LUO Li-ping, YANG Wu-liang, et al. Determination of Glycerin in Ibuprofen Oral Solution by HPLC-RID[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 61-63.
DOI：

LI Yan-gang, LUO Li-ping, YANG Wu-liang, et al. Determination of Glycerin in Ibuprofen Oral Solution by HPLC-RID[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 61-63. DOI： 10.11653/syfj2013120061.

摘要

目的: 建立高效液相色谱-示差折光检测法(HPLC-RID)测定布洛芬口服液中甘油含量的方法。方法: Waters Spherisorb NH2氨基柱(4.6 mm×250 mm

5.0 μm)

流动相乙腈-水(85:15)

流速1 mL·min-1

柱温30℃

RID温度35℃。结果: 甘油能被有效分离

线性范围0.881 2~88.12 μg

检测限和定量限分别为11.05

110.05 ng

加样回收率102.8%(RSD 1.4%)。结论: 该方法灵敏、简便、重复性好

为布洛芬口服溶液的质量控制提供参考。

Abstract

Objective: To establish a HPLC-RID method for determination of glycerin in ibuprofen oral solution. Method: Waters Spherisorb NH2 column (4.6 mm×250 mm

5.0 μm) was adopted with the mobile phase of acetonitrile-water (85:15)

column temperature 30℃

the flow rate was 1.0 mL·min-1 and RID temperature was 35℃. Result: This established method had good linear relationship within the range of 0.881 2-88.12 μg (r=0.999 9) for glycerin.The detection and quantitation limits were 11.05

110.05 ng respectively

the average recovery (n=5) was 102.8%(RSD 1.4%). Conclusion: This method was convenient

accurate and reliable

which could provide a reference for quality control of ibuprofen oral solution.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Content Determination of Sodium Benzoate and Acesulfame in Ibuprofen Oral Solution by HPLC

Related Author

DUAN Feng

Related Institution

No data

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰