Objective: To find the best matching dosage of Panax notoginseng and Ixeris sonchifolia Hance in Sanku dropping pills through observing the effect of its separated recipe on a acute myocardial ischemia. Method: The health Wistar rats were randomly divided into model group

Sanku dropping pills 2:8 (P. notoginseng:I. sonchifolia) high-dose group

3:7 high-dose group

4:6 high-dose group

2:8 middle-dose group

3:7 middle-dose group

4:6 middle-dose group

2:8 low-dose group

3:7 low-dose group

4:6 low-dose group

ig administration lasted 7 days. The animal model of acute myocardial ischemia was reduced by continuous intraperitoneal injection isopropylarterenol (20 mg·kg-1) during three days and observe the change of electrocardiogram S-T

myocardial enzyme in blood serum

and the index related to oxygen free radicals in myocardial tissue were observed. Result: It showed that

all the proportion group of Sanku dropping pills could decrease electrocardiogram ST(P<0.05

P<0.01

P<0.001)and the value of lactic clehydrogense(LDH) and creatine kinase(CK) in blood serum(P<0.05

P<0.01)

increase the activity of superoxide dismutase(SOD) and lessen the value of malondi aldehyde MDA in myocardial tissue(P<0.05

P<0.01)

but the effect and educe seasoning of dosage of 3:7 and 4:6 groups were inferior to dosage of 2:8 groups. Conclusion: The best matching dosage of P. notoginseng. and I. Sonchifolia in Sanku dropping pills were 2:8.