Objective: To observe the Rehmanniae Radix and Corni Fructus water extracts and drug-containing serum on the proliferation of advanced glycation and generatedproducts (AGEs). Method: The reaction system composed of 200 mmol·L-1 glucose and bovine serum albumin was added to the Rehmanniae Radix and Corni Fructus and its water extracts with different compatibility drug-containing serum to determine early glycated protein (fructosamine) at 530 nm after two weeks at 37℃ incubation;the excitation wavelength of 360 nm and emission wavelength at 460 nm were used for the determination of AGEs fluorescence value (F) at 37℃ after four weeks of incubation. Result: Rehmanniae Radix and Corni Fructus water extracts and drug-containing serum had a certain inhibitory effect on fructosamine and AGEs

and Rehmannia dride rhizome and common macrocarpium fruit decoction group inhibited fructosamine and AGEs more obvious than other groups. Conclusion: Rehmanniae Radix and Corni Fructus with different compatibility have a synergistic effect on the inhibition of fructosamine and AGEs.