Effect of Senqi Xiaobi Granules on Serum Levels of GH, EGF and GAS in Rats with Chronic Atrophic Gastritis

LI Jun-qing; LI Chun; LIU Xi; Wang Jing; SUN Jian-ning

doi:10.11653/syfj2013120172

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Effect of Senqi Xiaobi Granules on Serum Levels of GH, EGF and GAS in Rats with Chronic Atrophic Gastritis

更新时间：2024-01-04

- Effect of Senqi Xiaobi Granules on Serum Levels of GH, EGF and GAS in Rats with Chronic Atrophic Gastritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 12, Pages: 172-175(2013)
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- DOI：10.11653/syfj2013120172
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- Published：2013
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LI Jun-qing, LI Chun, LIU Xi, et al. Effect of Senqi Xiaobi Granules on Serum Levels of GH, EGF and GAS in Rats with Chronic Atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 172-175.
DOI：

LI Jun-qing, LI Chun, LIU Xi, et al. Effect of Senqi Xiaobi Granules on Serum Levels of GH, EGF and GAS in Rats with Chronic Atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 172-175. DOI： 10.11653/syfj2013120172.

摘要

目的: 观察参七消痞颗粒(SQ)对慢性萎缩性胃炎大鼠血清生长激素(growth hormone

GH)、表皮生长因子(epidermal growth factor

EGF)、胃泌素(gastrin

GAS)的影响。方法: 通过N-甲基-N'-硝基-N-亚硝基胍 (MNNG)负荷其他因素建立慢性萎缩性胃炎(chronic atrophic gastritis

CAG)大鼠模型(14周)

之后再随机分为模型组、摩罗丹组、叶酸组、参七消痞颗粒2

8 g·kg-1组。模型组给予生理盐水10 mL·kg-1

摩罗丹组灌胃摩罗丹3.6 g·kg-1

叶酸组灌胃叶酸2 mg·kg-1

共计8周。另从实验开始造模时就设立正常对照组。每周监测大鼠体重

第22周取材

观察大鼠胃的病理组织学改变

腹主动脉取血分离血清

放免法检测血清GH

EGF

GAS的含量。结果: 从第3周开始模型组大鼠与正常对照组相比

体重明显较轻(P<0.05);第22周

模型组大鼠胃容物恶臭

胃黏膜苍白

胃壁较薄

胃黏膜皱襞走向紊乱

HE切片镜下观察

固有层腺体减少

排列不规则

间隙较大

肠上皮化生明显

有异型增生

参七消痞颗粒各剂量组与模型组相比

肉眼及镜下观察均有不同程度的改善作用;血清GH水平

参七消痞颗粒8 g·kg-1组与模型组比较显著升高[(5.42±0.68)

(5.02±0.71)μg·L-1

P<0.05)];血清EGF水平

参七消痞颗粒4

2 g·kg-1组与模型组比较显著升高[(0.88±0.22)

(0.86±0.18)

(0.72±0.17)μg·L-1

P<0.01)];血清GAS水平

参七消痞颗粒4

2 g·kg-1组与模型组比较显著降低[(68.07±11.38)

(62.42±10.19)

(74.85±7.06) ng·L-1

P<0.05或P<0.01)]。结论: 参七消痞颗粒能明显改善慢性萎缩性胃炎大鼠的胃黏膜病变

其治疗机制可能与升高血清EGF水平、降低血清GAS水平有关。

Abstract

Objective: To evaluate the effect of Senqi Xiaobi(SQ) granules on serum levels of growth hormone(GH)

epidermal growth factor(EGF) and gastrin (GAS) in rats with chronic atrophic gastritis (CAG). Method: CAG model was established by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and other comprehensive factors for 14 weeks. Then the model rats were divided into 6 groups randomly

which were ig administered with saline

Moluodan

folic acid

SQ granules 2

8 g·kg-1

respectively

taking normal Wistar rats as control group at the beginning of modeling. Body weight of rats was observed for 22 weeks. In 22nd week

the pathological changes of gastric mucosa were observed

serum levels of GH

EGF GAS were measured by radioimmunoassay. Result: in 22nd week

in the model group

there were typical CAG pathological morphological changes on the gastric mucosa

Compared with model group

there were improvements on pathological changes at different degrees in the SQ Granules-treated groups; serum levels of GH in the SQ Granules 8 g·kg-1 group were significantly higher than that in the model group[(5.42±0.68)

(5.02±0.71 μg·L-1

P<0.05)];serum levels of EGF in the SQ granules 4

2 g·kg-1 group were significantly higher than that in the model group[(0.88±0.22)

(0.86±0.18)

(0.72±0.17)μg·L-1

P<0.01)]; serum levels of GAS in the SQ granules 4 g·kg-1 group and SQ granules 2 g·kg-1 group were significantly lower than that in the model group[(68.07±11.38)

(62.42±10.19)

(74.85±7.06) ng·L-1

P<0.05 or P<0.01)]. Conclusion: SQ granules improve mucosal atrophy possibly by increasing serum levels of GH

EGF and reducing serum levels of GAS in rats with chronic atrophic gastritis.

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