Objective: To investigate biological difference in hemorheology and erythrocyte membrane in rats with blood stasis caused by cold stagnationl. Method: Twenty Wistar rats were randomly assigned to blank control group and cold stagnation and blood stasis group

10 rats in each group. These rats were put into ice water (0-1℃) for 8-10 minutes until the rats were titanic everyday

and the duration of modeling aws 14 days. On the day of 15

0.8 mL·kg-1 adrenalin hydrochloride was subcutaneously injected

the interval duration was 4 hours.Hemorheology indexes and activity of erythrocyte membrane were determined after 15 days. Result: Compared with blank control group

weight of rats in model group was decreased significantly. The whole blood viscosity was increased significantly (P<0.05). There were no significant change in plasma viscosity and blood-fat. The red cell deformability index was decreased significantly (P<0.05). Blood sedimentation K value and the content of fibrinogen (FIB) of rats in model group was increased significantly. Activated partial thromboplastin time (APTT) was decreased significantly while thrombin time (TT) and prothrombin time (PT) showed no significant change. Super oxide dismutase (SOD) and Na+-K+-ATP enzyme activity of erythrocyte membrane were decreasing and the content of sialic acid was decreased (P<0.05). There was no significant change in the content of malondialdehyde (MDA) and plasma cholesterol. The content of hydrosulphonyl was no change. Conclusion: In cold stagnation and blood stasis model the decreased content of sialic acid

SOD and Na+-K+-ATP enzyme activity of erythrocyte can be found membrane which maybe one of the mechanism of increasing deformability of erythrocyte and improving the blood viscosity.