Objective: To screen the effective fractions of Sanjiu Weitai prescription for anti-gastric ulcer activity. Method: The SD rats were divided into eight groups

including normal control group

model group

positive control(cimetidine and Sanjiu Weitai granules)groups

petroleum ether extract group

ethyl acetate extract group

n-butyl alcohol extraction group and water extraction group

with different dose lavage for seven days. Rat experimental gastric ulcer model was induced by intragastric administration of ethanol. Gastric ulcer inhibition rate

pepsin activity

malondialdehyde(MDA) content and superoxide dismutase(SOD) activity in serum were determined to evaluate anti-gastric ulcer activities of different fractions extracted by petroleum ether

ethyl acetate

n- butanol and water extraction parts. Result: All of the extracts of Sanjiu Weitai prescription could significantly inhibit gastric mucosa damage in rats induced by ethanol (P<0.05). The gastric ulcer inhibition rate of petroleum ether extract was 89.15%

higher than those of Sanjiu Weitai capsules group (55.31%) and cimetidine group (59.90%). All of the extracts could significantly reduce pepsin activity (P<0.05) and increase activity of SOD in serum (P<0.05). Conclusion: All of the various polarity fractions of Sanjiu Weitai prescription can significantly inhibit gastric ulcer. The petroleum ether fraction exhibits the best anti-gastric ulcer activity.