Pharmacodynamics Study on Shufeng Ningtong Capsule

WANG Fang; ZHANG Xing; LIU Juan-juan; WANG Dong; WANG Ying; WANG Kun; LIU Zi-dong; LIU Yu-lin

doi:10.11653/syfj2013120231

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Pharmacodynamics Study on Shufeng Ningtong Capsule

更新时间：2024-01-04

- Pharmacodynamics Study on Shufeng Ningtong Capsule
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 12, Pages: 231-234(2013)
- 作者机构：
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- 基金信息：
- DOI：10.11653/syfj2013120231
  CLC：
- Published：2013
- 稿件说明：
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WANG Fang, ZHANG Xing, LIU Juan-juan, et al. Pharmacodynamics Study on Shufeng Ningtong Capsule[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 231-234.
DOI：

WANG Fang, ZHANG Xing, LIU Juan-juan, et al. Pharmacodynamics Study on Shufeng Ningtong Capsule[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 231-234. DOI： 10.11653/syfj2013120231.

摘要

目的: 研究舒风宁痛胶囊对痛风症的药理作用。方法: 以足跖注射1%的角叉菜胶造成大鼠足跖肿胀模型

观察舒风宁痛胶囊0.06

0.018

0.006 g·kg-1 ig 7

15 d对足跖厚度的影响。饲料中加入5%的氧嗪酸钾和1%的尿酸

15 g/只

限量喂食24 d造成大鼠痛风性肾病模型

观测给药11

24 d血尿酸水平。采用热板法和扭体反应测定给药7

15 d小鼠的痛阈

小鼠剂量均为0.1

0.03

0.01 g·kg-1。用酵母诱导出小鼠高尿酸血症

测定给药15 d血尿酸水平。结果: 舒风宁痛胶囊高量0.06

0.018 g·kg-1用药7~15 d后可显著对抗角叉菜胶诱发的大鼠足跖炎性肿胀。0.1

0.03 g·kg-1对小鼠具有显著的镇痛作用。舒风宁痛胶囊0.06

0.018 g·kg-1 11

24 d可显著对抗氧嗪酸钾诱发的大鼠高尿酸血症的血尿酸的水平

0.1

0.03 g·kg-1用药15 d可显著对抗酵母膏诱发的小鼠高尿酸血症的血尿酸的水平。结论: 舒风宁痛胶囊对痛风有良好的治疗作用。

Abstract

Objective: To study pharmacological effect of Shufeng Ningtong capsule (SNC) on gout. Method: Rat paw edema model was induced by injection of 1% carrageenan in footpad. SNC of 0.06

0.018

0.006 g·kg-1 (ig 7

15 d) was given to the model rats

and effect on paw thickness was investigated and analyzed. Gouty nephropathy model in rat was established by adding 5% oxonic acid potassium and uric acid 1% (15 g each rat) in the limited feed for 24 d. Mouse model of hyperuricemia was induced by yeast. Blood uric acid level was monitored at 11 d and 24 d. Pain threshold at 7

15 d in mice was determined by using hot plate method and writhing reaction.SNC dose in mice were 0.1

0.03

0.01 g·kg-1. Result: Rat footpad swelling induced by carrageenan was antagonized by SNC (0.06

0.018 g·kg-1) after 7-15 d. SNC (0.1

0.03 g·kg-1) showed significant analgesic effect in mice. SNC (0.06

0.018 g·kg-1

24 d) could significantly inhibit oxonic acid potassium induced rat hyperuricemia uric acid level. SNC (0.1

0.03 g·kg-1

15 d) could significantly decrease hyperuricemia uric acid in mouse model induced by yeast. Conclusion: SNC has good therapeutic effect on gout.

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