LIU Yu-hui, WANG Yue-sheng, WANG Yin-yi, et al. Study of Gegen Qinlian Decoction on Type 2 Diabetes in Rats and the Dose-effect Relationship[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 258-261.
DOI:
LIU Yu-hui, WANG Yue-sheng, WANG Yin-yi, et al. Study of Gegen Qinlian Decoction on Type 2 Diabetes in Rats and the Dose-effect Relationship[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 258-261. DOI: 10.11653/syfj2013120258.
Study of Gegen Qinlian Decoction on Type 2 Diabetes in Rats and the Dose-effect Relationship
Objective: To investigate the effects of Gegen Qinlian decoction on type 2 diabetes in rats and the dose-effect relationship
to obtain the dosage threshold of the classical prescription. Method: SD rats were randomly assigned into normal control group and diabetic model group
which was established by injection small dose of streptozotosin(STZ) (30 mg·kg-1) after feeding a diet with high glucose and lipids for 4 weeks. Diabetic rats were randomly assigned into model group
dimethylbiguanide group (200 mg·kg-1) and different dose of Gegen Qinlian decoction groups (1.65
4.95
8.25
11.55
14.85
18.15
21.45
24.75
28.05 g·kg-1 accordingly). The serum glucose
insulin
insulin resistance (IR)
glycosylated hemoglobin (HbA1c)
glycosylated serum protein (GSP) were determined. Result: Compared with model group
Gegen Qinlian decoction could decrease serum glucose
insulin
IR
HbA1c and GSP level(P<0.05
P<0.01). As dose of Gegen Qinlian decoction increased
the drug action was more obviously in the specified dose range. The dosage threshold of Gegen Qinlian decoction on diabetes in rats was 27.01-1.09 g·kg-1. Conclusion: The effect of Gegen Qinlian decoction on type 2 diabetes in rats shows fine dose-effect relationship.
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