Experimental Study on Effect of Modified Formula Rupixiao on Mammary Hyperplasia Rats

JIANG Yun-yun; YE Guang-ming; MU Wei; LIU Hai; CHEN Yun-hong

doi:10.11653/syfj2013120269

您当前的位置：

首页 >

文章列表页 >

Experimental Study on Effect of Modified Formula Rupixiao on Mammary Hyperplasia Rats

更新时间：2024-01-04

- Experimental Study on Effect of Modified Formula Rupixiao on Mammary Hyperplasia Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 12, Pages: 269-272(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013120269
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
JIANG Yun-yun, YE Guang-ming, MU Wei, et al. Experimental Study on Effect of Modified Formula Rupixiao on Mammary Hyperplasia Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 269-272.
DOI：

JIANG Yun-yun, YE Guang-ming, MU Wei, et al. Experimental Study on Effect of Modified Formula Rupixiao on Mammary Hyperplasia Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 269-272. DOI： 10.11653/syfj2013120269.

摘要

目的: 观察乳癖消减方对实验性大鼠乳腺增生的治疗作用。方法: 用苯甲酸雌二醇和黄体酮致大鼠乳腺增生模型

将大鼠随机分为空白对照组、模型对照组、乳癖消片组(生药4 g·kg-1)、乳癖消减方高、中、低剂量组(生药8

2 g·kg-1)

模型对照组15只

其余每组各10只。大鼠连续ig给药9周

用放射免疫法测定大鼠血清雌二醇、孕酮水平

并对第二、三对乳房常规固定染色后进行病理学检查。结果: 乳癖消减方低剂量组治疗效果不明显

乳癖消减方中、高剂量组不仅可以使乳腺增生大鼠雌二醇与孕酮的比值恢复正常(P<0.01)

且能显著改善模型大鼠乳腺增生引起的病理改变。结论: 乳癖消减方对大鼠乳腺增生具有显著的治疗作用。

Abstract

Objective: To observe the therapeutic effect of modified formula Rupixiao on mammary hyperplasia rats. Method: Rat models with hyperplasia of mammary glands were established by injection of estradiol benzoate and progesterone. The rats were randomly divided into control group

vehicle group

Rupixiao tablet group (4 g·kg-1) and modified formula Rupixiao groups (8

2 g·kg-1). There were 15 rats in vehicle group

and 10 rats in each of other group. The rats were orally administrated with drugs for 9 weeks. The contents of estradiol and progesterone in rat plasma were measured by radioimmunity

and the pathologic examination was carried out on the second and third pairs of breasts after usual fixation and staining. Result: Modified formula Rupixiao 2 g·kg-1 of did not have obvious therapeutic effect on mammary hyperplasia rats. Modified formula Rupixiao 4

8 g·kg-1could not only make the ratio of estradiol to progesterone back to normal(P<0.01)but also improved their pathologic status. Conclusion: Modified formula Rupixiao has conspicuous therapeutic effect on mammary hyperplasia rats.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Approach of the Mechanism of Xiaogengyanjing Capsule Treat Menopausal Syndrome

Related Author

YANG Ming1

FU Ping1

CHEN Ying-li1

WANG Qing1

WANG Yue-zhen2

LI Wei1

YANG Ming~1

FU Ping~1

Related Institution

Academy of Traditional Chinese Medicine and Material Medica of Jilin Province

JiLin Province Xidian Pharmceutical Sci-Tech Development Co.Ltp

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰