Ability of Learning and Memory of Offspring Affected by Exposure of Normal and Blood-stasis Pregnant Rats to Curcumae Rhizoma

ZOU Yu; LIU Yu-zhang; ZHANG Chun; FAN Li; ZHOU Li; NIU Ying-cai

doi:10.11653/syfj2013120278

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Ability of Learning and Memory of Offspring Affected by Exposure of Normal and Blood-stasis Pregnant Rats to Curcumae Rhizoma

更新时间：2024-01-04

- Ability of Learning and Memory of Offspring Affected by Exposure of Normal and Blood-stasis Pregnant Rats to Curcumae Rhizoma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 12, Pages: 278-280(2013)
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- DOI：10.11653/syfj2013120278
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- Published：2013
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ZOU Yu, LIU Yu-zhang, ZHANG Chun, et al. Ability of Learning and Memory of Offspring Affected by Exposure of Normal and Blood-stasis Pregnant Rats to Curcumae Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 278-280.
DOI：

ZOU Yu, LIU Yu-zhang, ZHANG Chun, et al. Ability of Learning and Memory of Offspring Affected by Exposure of Normal and Blood-stasis Pregnant Rats to Curcumae Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 278-280. DOI： 10.11653/syfj2013120278.

摘要

目的: 观察并比较莪术对正常和血瘀证孕大鼠子代学习记忆能力影响的差异。方法: Wistar雌性大鼠随机平均分为正常组和血瘀证模型组

采用0.1 mg/只sc盐酸肾上腺素与冰水浴相结合的方法制备大鼠血瘀证模型。造模结束后

按2:1雌雄合笼

受孕后正常组和血瘀证组孕鼠分别随机分为1.4

2.8

5.6 g·kg-1莪术组和对照组

共8个亚组。孕鼠于妊娠第6 d~19 d连续ig给予不同剂量的莪术水煎液

共给药14 d

于仔鼠生后28 d进行Morris水迷宫测试。结果: 正常大鼠和血瘀证大鼠给予莪术暴露后两者仔鼠学习记忆能力存在差异。在莪术高剂量组

第2

4天正常大鼠组仔鼠逃避潜伏期(44.87±10.99)s

(33.95±4.29)s

(23.29±3.56)s较血瘀组(38.11±5.40)s

(29.11±5.40)s

(19.59±2.58)s明显延长

过台次数(6.30±1.71)次

(5.15±1.18)次

明显减少(均P<0.05)

而血瘀证模型大鼠组仔鼠的逃避潜伏期和过台次数与对照组比较均无显著性差异。结论: 莪术对正常大鼠和血瘀证模型大鼠的仔鼠学习记忆能力损伤的影响具有差异

对正常大鼠的毒性效应更明显。

Abstract

Objective: In order to evaluate the differences in ability of learning and memory of offspring between normal and blood-stasis pregnant rats treated with Curcumae Rhizoma. Method: One hundred female Wistar rats were randomized into normal group and blood-stasis model group. A model of blood stasis model in rats by injecting adrenalin and simultaneously being immersed in ice water was used. The rats were mated and pregnant rats of two groups were randomized into the low

medium and large dose (1.4

2.8

5.6 g·kg-1) and control sub-group. Curcumae Rhizoma was orally administered to pregnant rats from gestational day (GD) 6 through 19 at dose levels of 0

1.4

2.8

5.6 g·kg-1. The functions of learning and memory of the infant rats from the postnatal day 28 to 32 were determined with Morris water maze. Result: There was a difference in ability of learning and memory of offspring between normal and blood-stasis pregnant rats treated with Curcumae Rhizoma. Compared with the blank group

the infant rats in normal pregnant group treated with Curcumae Rhizoma at 5.6 g·kg-1 had significantly longer escape latency to find the platform on postnatal day 29 to 31

whereas the number of crossings over a platform position was significantly decreased. We could not find any significant changes in that of blood-stasis rats group. Conclusion: Ability of learning and memory of offspring of normal pregnant rats was weaker than that of offspring of blood-stasis pregnant rats treated with Curcumae Rhizoma

confirmed the rationality of evaluating the toxicity of Chinese medicines based on traditional Chinese medicine syndrome theory.

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Related Author

XING Gui-hua

GAO Zhi-ying

NIU Ying-cai

XING Gui-hua

LIU Yu-zhang

ZOU Yu

ZHANG Chun

FAN Li

Related Institution

Institute of Medicine,Qiqihaer Medical College,Qiqihaer

Hubei Shizhen Laboratory

School of Traditional Chinese Medicine， Hubei University of Chinese Medicine

Engineering Research Center of Traditional Chinese Medicine Protection Technology and New Product Development for the Elderly Brain Health， Ministry of Education， Hubei University of Chinese Medicine

School of Basic Medical Sciences， Hubei University of Chinese Medicine

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