Objective: To observe the clinical efficacy on the treatment of chronic gastritis with masculine Helicobacter pylori (HP) by combination of traditional Chinese medicine (TCM) and western medicine. Method: Ninety patients were randomly divided into observation group and control group (n=45 each). Patients in two groups were treated with omeprazole capsules 20 mg

clarithromycin 500 mg and amoxicillin 1 000 mg (twice daily and ten days as one course) and Xiaoyou Huwei prescription (once a day

four weeks as one course) was applied in the observation group. Eradication rate of HP

spleen-stomach damp-heat syndrome and adverse reactions were recorded. Result: The negative conversion cases of HP in the observation group (35 cases

77.78%) were better than that of the control group (26 cases

57.78%) (P<0.05). The therapeutic efficacy of the observation group was significantly better than the control group (P<0.01). The effective rate of Chinese medicine syndrome in the observation group was better than the control group (P<0.01). Accumulating points of big belly

abdominal pain

epigastric burning

ozostomia

nausea and vomitting

spleen-stomach damp-heat syndrome in the observation group were better than those in the control group (P<0.01). No significant adverse reactions observed in the course of treatment. Conclusion: Combination of TCM and western medicine has better therapeutic efficacy

marked improvement in clinical symptoms and less adverse reactions

it could be chosen as the preferred alternative.