Influence of Compound Danshen Injections Combined with Naloxone on Head on Oxidative Stress and Inflammatory Factor of Neonatus with Hypoxic-ischemic Encephalopathy(HIE)

WANG Xin-jie

doi:10.11653/syfj2013120338

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Influence of Compound Danshen Injections Combined with Naloxone on Head on Oxidative Stress and Inflammatory Factor of Neonatus with Hypoxic-ischemic Encephalopathy(HIE)

更新时间：2024-01-04

- Influence of Compound Danshen Injections Combined with Naloxone on Head on Oxidative Stress and Inflammatory Factor of Neonatus with Hypoxic-ischemic Encephalopathy(HIE)
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 12, Pages: 338-340(2013)
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- DOI：10.11653/syfj2013120338
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- Published：2013
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WANG Xin-jie. Influence of Compound Danshen Injections Combined with Naloxone on Head on Oxidative Stress and Inflammatory Factor of Neonatus with Hypoxic-ischemic Encephalopathy(HIE)[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 338-340.
DOI：

WANG Xin-jie. Influence of Compound Danshen Injections Combined with Naloxone on Head on Oxidative Stress and Inflammatory Factor of Neonatus with Hypoxic-ischemic Encephalopathy(HIE)[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 338-340. DOI： 10.11653/syfj2013120338.

摘要

目的: 探讨复方丹参注射液联合纳洛酮对新生儿缺氧缺血性脑病(HIE)氧化应激和炎症的影响。方法: 102 例HIE患儿随机分为两组

对照组给予抗惊厥、吸氧、营养支持、降颅压及维持酸碱平衡等常规治疗

治疗组在常规治疗的基础上

纳洛酮0.05 mg·kg-1

静脉注射

随后0.04 mg·kg-1·h-1连续6 h泵入

共3~5 d;复方丹参注射液0.5~1.0 mL·kg-1

静滴

1次/d

连续10 d。比较治疗前、治疗第7天血清中超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、谷胱甘肽过氧化物酶(GSH-Px)、白细胞介素(IL)-6、超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子(TNF)-α水平

并对患儿进行NBNA评分。结果: 两组治疗第7天

两组MDA

IL-6

hs-CRP

TNF-α水平下降显著

SOD

GSH-Px上升显著(P<0.05或P<0.01);与对照组比较

治疗组的各指标变化幅度明显大于对照组(P<0.05)。新生儿神经行为评分(NBNA)比较

两组患儿治疗后14

28 d

治疗组明显高于对照组 (P<0.05)。结论: 复方丹参注射液联合纳洛酮能较好的抑制HIE患儿炎症反应

减轻缺氧缺血的氧化应激反应

改善机体神经功能。

Abstract

Objective: To explore influence of compound Danshen injections combined with Naloxone on head on oxidative stress and inflammatory factor neonatus with hypoxic-ischemic encephalopathy(HIE). Method: One hundred and two cases with HIE were randomly assigned into two group

the cases in control group were treated by conventional therapy and cases in treatment group were treated by compound danshen injections combined with naloxone at the base of conventional therapy

superoxide dismutase(SOD)

malondialdehyde (MDA)

nitric oxide (NO)

glutathione peroxidase (GSH-Px)

interleukin (IL)-6

high sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor (TNF-α) were measured at treatment before and treatment for seventh days.NBNA grade was compared. Result: compare before

MDA

IL-6

hs-CRP

TNF-α both groups decreased significantly

SOD

GSH-Px level both two groups increased significantly at seventh days(P<0.05-P<0.01)

indices change in treatment group was significantly better than those in the control group(P<0.05). After 14

28 d after therapy

the neonatal behavioral neurological assessment (NBNA) score at treatment group was higher than that at control group significantly (P<0.05). Conclusion: The treatment of compound Danshen injections combined with naloxone can inhibit inflammatory reaction and oxidative stress

improving the nerve function.

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