Optimization of Preparation and Formulation Technology for Sustained Release Pellets of Total Tanshinones from

LAI Chun-hua; QIU Tian-jian; ZHENG Qin; XIAO Ying; HU Peng-yi; PAN Jun-jie

doi:10.11653/syfj2013130018

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Optimization of Preparation and Formulation Technology for Sustained Release Pellets of Total Tanshinones from

更新时间：2024-01-04

- Optimization of Preparation and Formulation Technology for Sustained Release Pellets of Total Tanshinones from
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 13, Pages: 18-21(2013)
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- DOI：10.11653/syfj2013130018
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- Published：2013
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LAI Chun-hua, QIU Tian-jian, ZHENG Qin, et al. Optimization of Preparation and Formulation Technology for Sustained Release Pellets of Total Tanshinones from [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 18-21.
DOI：

LAI Chun-hua, QIU Tian-jian, ZHENG Qin, et al. Optimization of Preparation and Formulation Technology for Sustained Release Pellets of Total Tanshinones from [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 18-21. DOI： 10.11653/syfj2013130018.

摘要

目的: 制备丹参总酮缓释微丸并优选其处方工艺。方法: 采用固体分散体增溶技术及流化床上药技术制备载药丸芯

选取丙烯酸树脂NE30D(Eudragit NE30D)对载药丸芯进行包衣

通过单因素试验考察包衣增重、致孔剂种类和用量、抗黏剂、熟化时间和温度对包衣工艺的影响。结果: 优选的包衣工艺为Eudragit NE30D包衣增重5%

以20%乳糖为致孔剂

50%滑石粉为抗黏剂

熟化时间12 h

熟化温度40 ℃

包衣微丸呈良好缓释效果

体外释药过程基本符合一级释药模型。结论: 流化床上药法和流化床包衣法可用于制备丹参总酮缓释微丸

其体外释药缓慢、平衡。

Abstract

Objective: To prepare sustained release pellets of total tanshitones and optimize its formulation technology. Method: Drug-loaded pellets core was prepared by solid dispersion solubilization technology and fluidized bed technology

this pellets core was coated with Eudragit NE30D

single factor test was used to investigate effect of coating weight

type and dosage of porogen

anti-adhesive agent

curing time and temperature on coating technology. Result: Optimum coating technology was as following:coating weight of Eudragit NE30 5%

with 20% lactose as porogen

50% talcum powder as anti-adhesive agent

curing time 12 h

curing temperature 40 ℃.Coated pellets had good sustained release effect

in vitro release of this drug was in line with First-order release equation. Conclusion: Fluidized bed irrigation method and fluidized bed coating method could be adopted to prepare sustained release pellets of total tanshinones from Salvia miltiorrhiza with slow and stable in vitro release.

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