Preparation and Quality Control of Xiaoer Fuxie Topical Gel Ointments

LIU Hui-min; LIU Li; LIU Qiang; SONG Lu-yao

doi:10.11653/syfj2013130042

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Preparation and Quality Control of Xiaoer Fuxie Topical Gel Ointments

更新时间：2024-01-04

- Preparation and Quality Control of Xiaoer Fuxie Topical Gel Ointments
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 13, Pages: 42-44(2013)
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- DOI：10.11653/syfj2013130042
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- Published：2013
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LIU Hui-min, LIU Li, LIU Qiang, et al. Preparation and Quality Control of Xiaoer Fuxie Topical Gel Ointments[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 42-44.
DOI：

LIU Hui-min, LIU Li, LIU Qiang, et al. Preparation and Quality Control of Xiaoer Fuxie Topical Gel Ointments[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 42-44. DOI： 10.11653/syfj2013130042.

摘要

目的: 制备小儿腹泻外敷凝胶膏剂

并建立其质量控制方法。方法: 以吴茱萸、胡椒、丁香、肉桂提取物为主药

聚丙烯酸钠和卡波姆为凝胶骨架成分制备凝胶膏剂;采用TLC鉴别方中胡椒、丁香、肉桂

HPLC测定吴茱萸碱含量。结果: 制备的凝胶膏剂成型性好

具有适宜的机械强度和黏附性。TLC中检出胡椒、丁香、肉桂

分离度好、专属性强

阴性对照无干扰。HPLC吴茱萸碱在0.05~0.4 μg与峰面积呈良好线性关系

平均回收率99.3%(RSD 1.01%)。结论: 该制备工艺稳定合理

建立的质量控制方法准确、可靠、专属性强

可用于该制剂的质量评价。

Abstract

Objective:To prepare Xiaoer Fuxie topical gel ointments

and establish its quality control standards. Method: Gel ointments was prepared with extract of Fructus Evodiae

Fructus Piperis

Flos Caryophylli and Cortex Cinnamomi as materials

sodium polyacrylate and carbomer as gel skeleton matrix.Fructus Piperis

Flos Caryophylli and Cortex Cinnamomi were identified by TLC.The content of evodiamine was determined by HPLC. Result: Moldability of prepared gel ointments was good with a suitable mechanical strength and adhesion.Fructus Piperis

Flos Caryophylli and Cortex Cinnamomi were detected by TLC

characteristic identification was distinct and highly specific.Evodiamine showed a good linear relationship in the range of 0.05~0.4 μg (r=0.999 9) with an average recovery of 99.3% (RSD 1.01%). Conclusion: This preparation technology was stable and reasonable.This established quality control method was reliable

accurate and specific

which could be used for quality evaluation of Xiaoer Fuxie topical gel ointments.

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