Objective:To study the effect of Mahuang Jiazhu decoction on the serum interleukin-2(IL-2)and interferon-γ(IFN-γ) content of mice infected by RSV in the damp and cold environment

and the correlation of immune state of mice with damp and cold environment and chinese and western drugs under ecological medicine. Method: The serum IL-2 and IFN-γ contents were examined with ELISA in mice which were placed artificial climate box to mimic the environment of simulating cold-wet exopathogen

to analyze the effects of Mahuang Jiazhu decoction and cold-wet exopathogen on immune state of mice infected by RSV. Result: The IL-2 and IFN-γ contents in virus model group and cold-wet group were lower significantly (all P<0.001)(all P<0.001) than that in normal group. There was difference in IL-2

IFN-γ contents between virus model group and cold-wet groups (P<0.001

P<0.05). The IL-2 and IFN-γ contents in the Mahuang Jiazhu decoction group and Ribavirin group were higher significantly than that in virus model group and cold-wet plus virus model groups

respectively(P<0.001).But there was no difference in the IL-2 content between Mahuang Jiazhu decoction group and Ribavirin group.The IFN-γ contents in virus plus Mahuang Jiazhu decoction group was lower than that in virus plus Ribavirin group(P<0.001). The IFN-γ contents in cold-wet plus virus plus Mahuang Jiazhu decoction group was lower than that in virus plus Mahuang Jiazhu decoction group(P<0.01). Conclusion: The decreased immunity of mice can be caused cold-wet exopathogen and virus infection. Mahuang Jiazhu decoction and Ribavirin can improve the immune state of mice infected by RSV in the damp and cold environment.