Objective:To investigate the effects of Ziwan Wan on the hemorheological parameters

clotting time and lung presentations in rat fevered and bleeding model. Method: The SD rats were divided into blank control group

model compared group

Yunnan Baiyao 0.5 g·kg-1 group

Ziwan Wan (high

middle and low

5

2.5

1.25 g·kg-1 accordingly) dose group. The corresponding drugs were iggiven with dose of 20 mL·kg-1 twice a day

for 7 days. Except the blank control group

fevered and bleeding models were established. The hemorheological parameters

thrombin time(TT)

activated partial thromboplastin time(APTT)

the prothrombinase time(PT)

fibrinogen(FIB) and the signs of lung presentations were detected in these groups. Result: In the model group compared with blank control group

of whole blood viscosity and plasma viscosity were increased

TT

APTT and FIB were prolonged

PT significantly was shorten. The middle dose of Ziwan Wan could dramatically lower whole blood viscosity

plasma viscosity

APTT

TT and increase the content of FIB. The high dose of Ziwan Wan could significantly shorten the TT

Low dose of Ziwan Wan could significantly prolong PT. The whole blood viscosity

APTT

TT and FIB in the middle dose of Ziwan Wan group was respectively 200 s-1(5.50±0.15) mPa·s

30 s-1(7.64±0.19) mPa·s

5 s-1(13.70±0.51) mPa·s

1 s-1(32.38±2.06) mPa·s

APTT(17.11±0.78)s

TT(30.07±2.00)s

FIB(5.56±0.14) g·L-1;TT of high dose of Ziwan Wan group was that TT(30.74±2.96)s;PT of low dose of Ziwan Wan group was that PT(14.63±1.14)s

compared with the model group

P<0.05 or P<0.01.Ziwan Wan could improve lung injury related symptoms in fevered and bleeding model groups

The middle dosage showed the best effect. Conclusion: The middle dose of Ziwan Wan showed the effect of Cooling blood and hemostasis by ameliorating the abnormal hemorheological parameters. The middle dose of Ziwan Wan is effective for hemostasis

and plays roles by ways of endogenous thrombin

extrinsic thombin and fibrin. The high dose of Ziwan Wan has certain effect for part of the abnormal hemorheological parameters and hemostasis parameters. Three doses of Ziwan Wan showed therapeutical effect in damaged lungs in fevered and bleeding model.