Objective:To study the effect of Huogu Dan capsule on hemorheology

blood lipids

blood calcium and bone metabolism indicators of avascular necrosis of femoral head by hormone in rats. Method: Sixty SD rats were divided into 6 groups

the control group

the model group

the high

medium

low-dose group (1.80

0.90

0.45 g·kg-1)

the positive drug group(0.28 g·kg-1). Except the normal group

each group was im given once a week prednisolone (24.5 mg·kg-1). Meanwhile each dose group was ig Huogu dan capsule.After 8 weeks rats were sacrificed to collect blood from carotid artery for determination of the whole blood viscosity

plasma viscosity

ESR

the serum total cholesterol(CHO)

triglycende(TG)

alkaline phosphatase(ALP)

acid phosphatase(ACP)

serum calcium(Ca) and phosphorus(P). Result: Compared with the control group

the whole blood viscosity in the model group was significantly increased (P<0.01). ESR values and plasma viscosity were significantly increased (P<0.01). CHO

TG and ALP levels were significantly increased (P<0.01). Ca level was increased (P<0.05).Compared with model group

Ca and P levels were significantly increased in the Huogu dan group

ALP and ACP were reduced

whole blood viscosity

plasma viscosity and blood lipids were reduced

statistical significance is different (P<0.05

P<0.01). Conclusion: The Huogu Dan capsule can be significantly increased Ca and P levels

and reduce ALP

ACP levels

whole blood viscosity

plasma viscosity and blood lipids.