Effects of Total Flavones from  on Gonadal Hormone in Animal Model of Ovulation Failure

LUO Ke-yan; YANG Dan-li; XU Min

doi:10.11653/syfj2013130258

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Effects of Total Flavones from on Gonadal Hormone in Animal Model of Ovulation Failure

更新时间：2024-01-04

- Effects of Total Flavones from on Gonadal Hormone in Animal Model of Ovulation Failure
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 13, Pages: 258-260(2013)
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- DOI：10.11653/syfj2013130258
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- Published：2013
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LUO Ke-yan, YANG Dan-li, XU Min. Effects of Total Flavones from on Gonadal Hormone in Animal Model of Ovulation Failure[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 258-260.
DOI：

LUO Ke-yan, YANG Dan-li, XU Min. Effects of Total Flavones from on Gonadal Hormone in Animal Model of Ovulation Failure[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 258-260. DOI： 10.11653/syfj2013130258.

摘要

目的: 探讨丝子总黄酮对排卵障碍大鼠下丘脑-垂体-卵巢(HPO)轴性激素水平的影响。方法: 将大鼠分为对照组(C)、模型组(M)、菟丝子黄酮低、高剂量组(CCLD

CCHD)以及阳性对照枸橼酸氯米芬组(PC)

采用羟基脲以300 mg·kg-1ig 连续进行10 d制作排卵障碍大鼠模型

用不同剂量菟丝子总黄酮(10

20 mg·kg-1)及阳性对照

4.5 mg·kg-1 ig连续5 d干预。放射免疫法观察并比较大鼠血清卵泡刺激素(FSH)、雌激素(E2)、促黄体生成素(LH)以及孕激素(P)水平的变化。结果: 与C组相比

M组血清FSH

E2及P水平显著降低(均P＜0.05)

其中FSH由(8.18±1.37) U·L-1降低至(4.22±0.94)U·L-1;LH由(17.25±5.36)U·L-1降低至(7.81±1.39)U·L-1;E2由(48.59±8.11)μg·L-1降低至(23.18±7.62)μg·L-1;P由(16.02±4.83)μg·L-1降低至(5.94±1.02)μg·L-1(均P＜0.05)。与M组相比

CCLD

CCHD以及PC组血清FSH

E2及P水平显著升高(均P＜0.05)。其中PC组与CCHD组FSH

E2及P水平较CCLD组升高更为明显(均P＜0.05)。结论: 菟丝子黄酮可显著改善排卵障碍大鼠HPO轴性激素水平

且以高剂量更为有效。

Abstract

Objective:To explore the effects of total flavones from Cuscuta chinensis (TFCC) on gonadal hormone in animal model of ovulation failure. Method: Animal model of ovulation failure was induced by intragastric administration of hydroxy urea

intragastric administration of TFCC was applied after establishment of ovulation failure; clomifene citrate was applied as positive control. Serum levels of FSH

E2 and P were observed in control group (C)

model group (M)

TFCC low dose group (CCLD)

TFCC high dose group (CCHD) and positive control group (PC) by radioimmunoassay method. Result: Compared with C

FSH

E2 and P decreased significantly in M (P<0.05). Compared with M

serum levels of FSH

E2 and P increased significantly in CCLD

CCHD and PC groups (P<0.05)

more significantly in CCHD and PC groups (P<0.05). Conclusion: TFCC shows significant effect in improving recovery of gondadal hormone level in rat with ovulation failure

more significant when applied at high dose.

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