Objective:To compare the pharmacological effects between the powdered Xuanfei Huatan decoction (PXHD) and the ordinary decoction (OXHD) of the same prescription. Method: A variety of experimental models was used

and rats

mice and guinea pigs were involved in the study. Rats were divided into eight groups. The rats in different groups were given distilled water

JI-ZHI syrup

3 doses of DXHD (46.80

23.40

11.70 g·kg-1) and 3 doses of PXHD (23.40

11.70

5.85 g·kg-1) respectively. The pharmacodynamic comparison between SXHD and OXHD included the follows:ammonia-induced cough in mice

phosphorylation histamine-induced asthma in guinea pigs

tracheal secretion of phenol red in mice

capillary permeability in mice and superoside dismutas(SOD) and malondialdehyde(MDA) in rats with chronic bronchitis. Result: PXHD and OXHD both could prolong the incubation period and reduce the cough frequency in mice;extend the latent period of asthma in guinea pigs;increase the amount of tracheal secretion of phenol red;reduce capillary permeability

and increase SOD and reduce MDA in rat with chronic bronchitis. No significant difference was found between the according level of PXHD and OXHD. Conclusion: Both PXHD and OXHD have the ability of suppressing cough

asthma and phlegm

and the ability of anti-inflammatory and antioxidant.