Objective:To investigate the anti-inflammatory activity of total flavonoids from Syneilesis aconitifolia. Method: Mice were involved in the study. The auricle edema was induced by dimethylbenzene

the abdominal cavity capillary permeability was increased by acetic acid

the granuloma was induced with cotton pellet

and the acute inflammation was induced by air-pouch. The anti-inflammatory effect of total flavonoids in different models were observed. Mice were divided into five groups

total flavonoids from S. acontifolia high dose

middle dose and low dose (400

200

100 mg·kg-1) groups

dexamethasone (2.0 mg·kg-1) group and the model group (normal saline). The drug treatment lasted 7 days. Result: The total flavonoids from S. acontifolia showed significant inhibitory action on auricle edema induced by dimethylbenzene in mice (P<0.01)

the inhibitory rate was 51.55%. The total flavonoids from S. acontifolia showed significant inhibitory action on penetration of capillary vessel in mice (P<0.01). The flavonoids also decreased the proliferation of granuloma caused by implantation cotton pellet in mice significantly. The amount of WBC and content of prostaglanding E2(PGE2) in the exudates in experimental groups were obviously lower than those in the control group (P<0.01). Conclusion: The total flavonoids from S. aconitifolia have significant anti-inflammation action

which is likely related to the decrease in capillary permeability and inhibition of production and release of the inflammatory factor PGE2.