Influence of Bushen Tongluo Fang on Diabetic Peripheral Neuropathy Oxidative Stress

ZHANG She-feng; YANG Chen-hua

doi:10.11653/syfj2013130297

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Influence of Bushen Tongluo Fang on Diabetic Peripheral Neuropathy Oxidative Stress

更新时间：2024-01-04

- Influence of Bushen Tongluo Fang on Diabetic Peripheral Neuropathy Oxidative Stress
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 13, Pages: 297-300(2013)
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- DOI：10.11653/syfj2013130297
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- Published：2013
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ZHANG She-feng, YANG Chen-hua. Influence of Bushen Tongluo Fang on Diabetic Peripheral Neuropathy Oxidative Stress[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 297-300.
DOI：

ZHANG She-feng, YANG Chen-hua. Influence of Bushen Tongluo Fang on Diabetic Peripheral Neuropathy Oxidative Stress[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 297-300. DOI： 10.11653/syfj2013130297.

摘要

目的: 观察补肾通络方对糖尿病周围神经病变(DPN)氧化应激影响。方法: 将48例DPN患者随机分为治疗组30例

对照组18例

两组均给予常规治疗+硫辛酸针

治疗组在对照组基础上配合补肾通络方治疗

疗程90 d。观察患者临床疗效及血糖、糖化血红蛋白(HbA1c)、甘油三酯(TG)、总胆固醇(CHOL)、神经传导速度、丙二醛(MDA)、超氧化物歧化酶(SOD)的变化。结果: 治疗后总有效率治疗组83.3%

对照组为66.7%

两组比较差异显著(P<0.05)。两组治疗后空腹血糖(FBG)

HbA1c

CHOL较治疗前显著下降(P<0.05);且治疗组TG

CHOL下降明显优于对照组(P<0.05)。治疗后两组运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)较治疗前明显提高(P<0.01

P<0.05);治疗组提高明显优于对照组(P<0.01)。治疗后两组MDA较治疗前明显下降

SOD较治疗前明显提高(P<0.01

P<0.05);治疗组MDA下降、SOD提高明显优于对照组(P<0.01)。结论: 在对照组治疗基础上配合补肾通络方治疗DPN可以提高临床疗效

改善血脂代谢

降低氧化应激反应

提高神经传导速度。

Abstract

Objective:To observe the influence Bushen Tongluo fang on diabetic peripheral neuropathy (DPN) oxidative stress. Method: Fourty-eight DPN patients were randomly divided into 2 groups

30 cases in treatment group and 18 cases in control group

two groups were given conventional treatment and lipoic acid for 90 days

in the same time the treatment group were given Bushen Tongluo fang. The clinical curative effect and changes of blood sugar

haemoglobin A1c (HbA1c)

triglyceride (TG)

total cholesterol(CHOL)

nerve conduction velocity

malondialdehyde (MDA)

superoxide dismutase (SOD) were observed. Result: After treatment

the total effective rate of treatment group was 83.3%

and the placebo group was 66.7%. Between the two groups

the difference was significant (P<0.05). The levels of fasting blood glucose(FBG)

HbA1c

CHOL in two groups were significant declined than before (P<0.05)

and TG

CHOL declined was better in treatment group than control group (P<0.05). After treatment

motor nerve conduction velocity(MNCV)

sensory nerve conduction velocity(SNCV) in two groups were obviously improved than before (P<0.01

P<0.05)

and the improvement in treatment group was better than control group (P<0.01). After treatment

MDA was markedly reduced (P<0.01) and SOD obviously improved (P<0.01

P<0.05) in two groups

and the effect in treatment group was better than control group (P<0.01). Conclusion: Bushen Tongluo fang on the basis of conventional treatment and lipoic acid in the treatment of DPN patients can improve the clinical curative effect

improve lipid metabolism

reduce oxidative stress reaction and improve nerve conduction velocity.

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Related Author

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Related Institution

The First Clinical School of Medicine， Shaanxi University of Chinese Medicine

Key Laboratory of Traditional Chinese Medicine （TCM） and Health Sciences， Ministry of Education， Beijing University of Chinese Medicine

Dongzhimen Hospital， Beijing University of Chinese Medicine

Chengdu University of TCM

College of Integrated Traditional Chinese and Western Medicine，Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns，Hebei University of Chinese Medicine

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