Objective:To observe the effect of heart and kidney-reinforcing formula related indicators and the plasma brain natriuretic peptide (BNP) of in chronic heart failure patients. Method: Forty cases with chronic heart failure patients based on double blind method were randomly divided into two groups. The two groups were given the same basic treatment

including low salt diet

bed rest

when necessary

the condition of oral inhalation and routine western medicine (ACEI

diuretics

vasodilators

digitalis

beta blockers) were carried out. The treatment group was given the heart-kidney treatment of cardiac double compensation

boiling juice 150 mL

2 times a day

course of treatment lasted8 weeks.The following indexes were observed and record ed before and after treatment

symptoms

tongue

pulse and cardiac ultrasound index

left ventricular end diastolic diameter(LVEDD)

end systolic diameter(LVESD)

ejection fraction (EF)

determination of plasma BNP

endothelin (ET) and nitric oxide content. And recorded before and after the treatment of safety indexes

such as blood pressure

electrocardiogram

liver and kidney function

blood rheology

blood

urine routine. A detailed record of drug adverse reactions. Result: The plasma ET

LVEDD

LVESD

NO levels were significantly reduced compared with before treatment (P<0.05)

BNP levels were significantly reduced (P<0.01)

ejection fraction EF were increased significantly (P<0.01). Conclusion: The heart and kidney-reinforcing formula is effective and safe.