Clinical Observation on Therapeutic Effect of Shenling Baizhu Powder Treating Chronic Otitis Media with Effusion in Spleen Deficiency Type

JIANG Yin-hui; TONG Qing-zhong; CHEN Shan-shan; Wang Jing; TAN Xiu-zhen

doi:10.11653/syfj2013130311

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Clinical Observation on Therapeutic Effect of Shenling Baizhu Powder Treating Chronic Otitis Media with Effusion in Spleen Deficiency Type

更新时间：2024-01-04

- Clinical Observation on Therapeutic Effect of Shenling Baizhu Powder Treating Chronic Otitis Media with Effusion in Spleen Deficiency Type
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 13, Pages: 311-314(2013)
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- DOI：10.11653/syfj2013130311
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- Published：2013
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JIANG Yin-hui, TONG Qing-zhong, CHEN Shan-shan, et al. Clinical Observation on Therapeutic Effect of Shenling Baizhu Powder Treating Chronic Otitis Media with Effusion in Spleen Deficiency Type[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 311-314.
DOI：

JIANG Yin-hui, TONG Qing-zhong, CHEN Shan-shan, et al. Clinical Observation on Therapeutic Effect of Shenling Baizhu Powder Treating Chronic Otitis Media with Effusion in Spleen Deficiency Type[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 311-314. DOI： 10.11653/syfj2013130311.

摘要

目的: 研究参苓白术散对脾虚型慢性分泌性中耳炎患者的治疗作用。方法: 随机纳入脾虚型慢性分泌性中耳炎患者60例

分为中西药结合实验组

给予参苓白术散合并考夫克与头孢美特酯治疗;西药对照组仅给予考夫克与头孢美特酯;每组均为30例

并设空白对照组15例

为健康人群。1个疗程(14 d)后用酶联免疫吸附测定(ELISA)法检测各组患者血清白细胞介素(IL)-4

IL-6及干扰素-γ(IFN-γ)浓度变化

并比较各组临床疗效。结果: ①实验组临床疗效明显优于对照组(P<0.05);②实验组、对照组给药前血清IL-4

IL-6与对照组相比显著升高

IFN-γ显著降低(P<0.01);③1个疗程后实验组、对照组血清IL-4

IL-6水平均下调

IFN-γ均上升

实验组均优于对照组(P<0.05)。结论: 参苓白术散治疗脾虚型慢性分泌性中耳炎对提高治愈率与改善临床症状方面均有显著效果

其机制可能与改善患者变态反应

调节免疫应答有关。

Abstract

Objective:To study the therapeutic effect of Shenling Baizhu powder on chronic otitis media with effusion (OME) in a spleen deficiency type. Method: Sixty patients of OME in a spleen deficiency type were included in the trial.The patients were randomLy divided into experimental group

drug treating group

and 30 healthy people were included as control group.After one course of treatment (14 days)

to test the serum concentration of interleukin(IL)-4

IL-6 and interferon-γ(IFN-γ) of each group by ELISA

and to compare the clinical efficacy of each group. Result: ①experimental group had a better therapeutic effect than drug treating group(P<0.05);②compared to control group

both experimental group and drug treating group had lower serum concentration of IFN-γ and higher concentration of IL-4

IL-6(P<0.01);③after one course of treatment(14 days)

the serum concentration of IL-4

IL-6 had been downregulated

IFN-γ had been upregulated

experimental group was surperior to drug treating group. Conclusion: Shenling Baizhu powder had a significantly clinical efficacy on chronic otitis media with effusion in a spleen deficiency type

and can media the immune response

so it is worthy to promote it being used widely.

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