Objective:To observe the impact of the Huxin formula therapy in ventricular remodeling and heart function of the patients with acute myocardial infarction. Method: Sixty-six patients were randomly divided into observation group and control group. Patients in two groups were both given conventional treatment. Huxin formula orally for 8 weeks) was given to the patients in the observation group. Echocardiography was used to check the heart function before and after treatment. Angiotensin II (Ang II)

transforming growth factor β1 (TGF β1)

vascular superoxide dismutase (SOD)

serum procollagen IIIN-terminal propeptide (PIIINP) and aldosterone (ALD) levels were detected and Qi stagnancy and blood stasis syndrome score was also observed. Result: Left ventricular end-diastolic diameter (LVDd)

left ventricular end-diastolic volume (LVEDV)

left ventricular end-systolic volume (LVSDV)

cardiac index (CI) and left ventricular ejection (LVEF) of patients in the observation group were significant improved after treatment (P<0.05

P<0.01)

and improvement of LVEDV and LVEF were better than the patients in the control group (P<0.05). AngⅡ

PⅢNP

ALD and TGF β1 of the patients in the observation group were lower than patients in the control group (P<0.05

P<0.01)

SOD level of the patients in observation group was higher than the patients in control group

scores of precordial pain

shortness of breath

palpitation

chest tightness

irritability and Qi stagnancy and blood stasis in observation group was lower than those in the control group. Conclusion: Huxin formula therapy can prevent ventricular remodeling after myocardial infarction

it can also improve clinical symptoms and heart function.