Effect of Zhipiantong Capsule on Treatment of Migraine and its Influence on Plasma 5-HT

MEN Ling; ZHANG Hong-qin

doi:10.11653/syfj2013130336

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Effect of Zhipiantong Capsule on Treatment of Migraine and its Influence on Plasma 5-HT

更新时间：2024-01-04

- Effect of Zhipiantong Capsule on Treatment of Migraine and its Influence on Plasma 5-HT
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 13, Pages: 336-339(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013130336
  CLC：
- Published：2013
- 稿件说明：
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MEN Ling, ZHANG Hong-qin. Effect of Zhipiantong Capsule on Treatment of Migraine and its Influence on Plasma 5-HT[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 336-339.
DOI：

MEN Ling, ZHANG Hong-qin. Effect of Zhipiantong Capsule on Treatment of Migraine and its Influence on Plasma 5-HT[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 336-339. DOI： 10.11653/syfj2013130336.

摘要

目的: 探讨治偏痛胶囊治疗偏头痛的疗效及对血浆5-羟色胺(5-HT)的影响。方法: 将124例偏头痛患者随机分为观察组和对照组各62例。对照组采用氟桂利嗪胶囊

5 mg/次

每晚服用1次;观察组采用治偏痛胶囊

4粒/次

3次/d

口服。治疗期间若发生难以忍受疼痛

均可采用布洛芬片

0.1 g/次

口服。两组疗程均为8周。观察头痛发作次数、头痛发作天数、头痛发作程度等临床症状;经颅多普勒(TCD)检测血液速度;检测血浆5-HT水平。结果: 观察组总有效率(90.32%)优于对照组(77.41%)(P<0.05);观察组证候疗效总有效率(91.93%)优于对照组(75.81%)(P<0.05);治疗后观察组头痛发作次数、头痛发作程度及头痛发作天数均低于对照组(P<0.01);治疗后观察组血浆5-HT水平升高

优于对照组(P<0.01);观察组在研究期间止痛药使用量低于对照组(P<0.01);观察组双侧大脑中动脉(MCA)

大脑前动脉(ACA)

大脑后动脉(PCA)

椎动脉的颅内段(VA)和基底动脉(BA)的血流速度均低于对照组(P<0.01)。结论: 治偏痛胶囊能降低颅内动脉平均血流速度

改善偏头痛临床症状

治疗偏头痛疗效显著

其作用机制可能与提高患者血浆5-HT含量有关。

Abstract

Objective:To investigate the effect of zhipiantong capsule for treatment of migraine and its influence on plasma 5-hydroxy tryptamine(5-HT). Method: One hundred and twenty-four patients with migraine were randomly divided into observation group and control group (n=62 each). Control group was orally received flunarizine capsules 5 mg at night daily. Observation group was orally received Zhipiantong capsules

4 capsules

tid. If patients feel unbearable pain during treatment

they were orally received ibuprofen tablets

0.1 g. The treatment course of two groups was 8 weeks. Frequencies

days

extent and associated symptoms of migraine were observed. Blood flow velocity was determined by transcranial Doppler (TCD)

and plasma 5-HT was tested. Result: The total curative effective rate of observation group (90.32%) was higher than that of control group (77.41%) with a significant difference (P<0.05). The total syndrome effective rate of observation group (91.93%) was higher than that of control group (75.81%) with a significant difference (P<0.05). After treatment

frequencies

days and extent of migraine in observation group were lower than those in control group (P<0.01). Plasma 5-HT level in observation group was higher than that in control group (P<0.01). The dosage of analgesic drugs used in observation group was less than those in control group during treatment. Blood flow velocity in middle cerebral artery(MCA)

anterior cerebral artery(ACA)

posterior cerebral artery(PCA)

intracranial segment of the vertebral artery(VA) and basilar artery (BA) in the observation group was slower than those in control group (P<0.01). Conclusion: Zhipiantong capsule can decrease the mean blood flow velocity in cerebral arteries

improve migraine clinical symptoms and treat migraine effectively

the mechanism of which may be related to increasing plasma 5-HT.

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Related Institution

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Graduate School of Anhui University of Chinese Medicine

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