Systematic Review on Yanhuning Combined with Ribavirin in Treatment of Hand-food-mouth Disease

LUO Qin-hong; GU Zi-juan; LIANG Jin-zhi; FANG Yi-sheng

doi:10.11653/syfj2013130351

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Systematic Review on Yanhuning Combined with Ribavirin in Treatment of Hand-food-mouth Disease

更新时间：2024-01-04

- Systematic Review on Yanhuning Combined with Ribavirin in Treatment of Hand-food-mouth Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 13, Pages: 351-355(2013)
- 作者机构：
- 作者简介：
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- DOI：10.11653/syfj2013130351
  CLC：
- Published：2013
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LUO Qin-hong, GU Zi-juan, LIANG Jin-zhi, et al. Systematic Review on Yanhuning Combined with Ribavirin in Treatment of Hand-food-mouth Disease[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 351-355.
DOI：

LUO Qin-hong, GU Zi-juan, LIANG Jin-zhi, et al. Systematic Review on Yanhuning Combined with Ribavirin in Treatment of Hand-food-mouth Disease[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(13): 351-355. DOI： 10.11653/syfj2013130351.

摘要

目的:评价炎琥宁与利巴韦林治疗手足口病的疗效和安全性。方法:计算机检索Pubmed

CENTRAL

CBM

CNKI

VIP和万方等中英文数据库

纳入随机对照文献(RCT)

由两名评价员独立选择试验和评价质量后

提取有效数据进行Meta分析。结果:共纳入26个RCT

病例共3 571例。Meta分析结果显示

炎琥宁联合利巴韦林治疗手足口病在总有效率[OR=5.72

95%CI(4.17

7.85)]、退热时间[MD=-1.16

95%CI(-1.46

-0.85)]、疱疹消退时间[MD=-1.56

95%CI(-1.87

-1.25)]、溃疡消退时间[MD=-1.11

95%CI(-1.47

-0.75)]等方面均优于对照组(P<0.05)。结论:炎琥宁联合利巴韦林对治疗手足口病可能有一定疗效

但还需进行更多高质量的RCT才能对其疗效得出肯定性结论。

Abstract

Objective:To evaluate the effectiveness and safety of Yanhuning combined with and ribavir in treatment of the hand-foot-mouth disease. Method: Pubmed

CENTRAL

CBM

CNKI

VIP and Wanfang database were searched for clinical trials.Two evaluators chose trials and evaluated quality

valid data were put in Meta-analysis.Result:Twenty-six randomized clinical trials(RCT) and three thousand five hundred and seventy-one patiences were included. From the results of Meta-analysis

the effectiveness of Yanhuning combined with ribavirin was superior than the control group in the overall efficiency [OR=5.72

95%CI(4.17

7.85)]

defervescence time [MD=-1.16

95%CI(-1.46

-0.85)]

simplex subsiding time [MD=-1.56

95%CI(-1.87

-1.25)]

and ulcer subsiding time [MD=-1.11

95%CI(-1.47

-0.75)].Conclusion: It may have a certain effect on curing the hand foot mouth disease when Yanhuning combined with ribavirin. But we need more high-quality RCT to support our inference and make an exact conclusion for its efficacy.

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Related Author

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Related Institution

Beijing Hospital of Traditional Chinese Medicine， Capital Medical University

Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province and Education Ministry of P.R. China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease，Henan University of Chinese Medicine

The First Affiliated Hospital of Henan University of Chinese Medicine

The First Clinical Medical School of Henan University of Chinese Medicine

The First Clinical College of Nanjing University of Chinese Medicine

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