Degradation Kinetics Analysis of Main Ingredients in Salvianolate Lyophilized Injection

ZHANG Hui-jie; REN Xiao-liang; CUI Ming-lei; PU Wei-ling; MA Si-meng; QI Ai-di

doi:10.11653/syfj2013140001

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Degradation Kinetics Analysis of Main Ingredients in Salvianolate Lyophilized Injection

更新时间：2024-01-04

- Degradation Kinetics Analysis of Main Ingredients in Salvianolate Lyophilized Injection
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 14, Pages: 1-5(2013)
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- DOI：10.11653/syfj2013140001
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- Published：2013
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ZHANG Hui-jie, REN Xiao-liang, CUI Ming-lei, et al. Degradation Kinetics Analysis of Main Ingredients in Salvianolate Lyophilized Injection[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 1-5.
DOI：

ZHANG Hui-jie, REN Xiao-liang, CUI Ming-lei, et al. Degradation Kinetics Analysis of Main Ingredients in Salvianolate Lyophilized Injection[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(14): 1-5. DOI： 10.11653/syfj2013140001.

摘要

目的: 探索注射用丹参多酚酸中主要活性成分(丹酚酸B和迷迭香酸)在不同pH和温度下的降解规律。方法: 采用HPLC测定迷迭香酸、丹酚酸B含量

研究二者在不同pH(1~13)和温度(60

90℃)下含量变化

通过化学动力学法计算降解动力学参数。结果: 丹酚酸B与迷迭香酸在不同pH和温度下降解反应均属于一级动力学反应

降解速率随pH及温度的升高而增加。丹酚酸B和迷迭香酸在水溶液中的降解活化能(Ea)分别为48.54

49.83 kJ·mol-1

在注射用丹参多酚酸中则分别为95.19

83.56 kJ·mol-1。结论: 丹酚酸B与迷迭香酸在碱性条件及高温条件下易降解

与对照品相比较

二者在注射用丹参多酚酸中更为稳定。

Abstract

Objective: To investigate degradation kinetics of main ingredients (salvianolic acid B and rosmarinic acid) of salvianolate lyophilized injection under different pH and temperatures. Method: HPLC was adopted to determine the content of salvianolic acid B and rosmarinic acid at different pH values and temperatures

degradation kinetic parameters of these two ingredients were evaluated by chemical kinetics. Result: Reaction of salvianolic acid B and rosmarinic acid at different pH values and temperatures were accord with the first-order kinetics

degradation rate accelerated by increasing of pH value and temperature.According to arrhenius equation

activation energy (Ea) of salvianolic acid B in aqueous solution and salvianolate lyophilized injection were 48.54

95.19 kJ·mol-1

respectively.Ea of rosmarinic acid in aqueous solution and salvianolate lyophilized injection were 49.83

83.56 kJ·mol-1

respectively. Conclusion: Salvianolic acid B and rosmarinic acid were sensitive to strong alkaline and high temperature conditions

but salvianolate lyophilized injection could obviously improve their stability.

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